Molecular determinants of cAMP-mediated regulation of the Na+-Ca2+ exchanger expressed in human cell lines.
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Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMPPhospholemman inhibition of the cardiac Na+/Ca2+ exchanger. Role of phosphorylation.The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na(+) /Ca(2+) exchanger and increasing intracellular Ca(2+).beta-adrenergic regulation of a novel isoform of NCX: sequence and expression of shark heart NCX in human kidney cellsInduced pluripotent stem cells as cardiac arrhythmic in vitro models and the impact for drug discovery.A new cell-penetrating peptide that blocks the autoinhibitory XIP domain of NCX1 and enhances antiporter activity.Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects.Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger.Involvement of the Na+/Ca2+ exchanger isoform 1 (NCX1) in neuronal growth factor (NGF)-induced neuronal differentiation through Ca2+-dependent Akt phosphorylation.ERK1/2, p38, and JNK regulate the expression and the activity of the three isoforms of the Na+ /Ca2+ exchanger, NCX1, NCX2, and NCX3, in neuronal PC12 cells.Beta-adrenergic stimulation does not activate Na+/Ca2+ exchange current in guinea pig, mouse, and rat ventricular myocytes.Cells expressing unique Na+/Ca2+ exchange (NCX1) splice variants exhibit different susceptibilities to Ca2+ overload.NCX1 phosphorylation dilemma: a little closer to resolution. Focus on "Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A".
P2860
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P2860
Molecular determinants of cAMP-mediated regulation of the Na+-Ca2+ exchanger expressed in human cell lines.
description
2003 nî lūn-bûn
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2003年の論文
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name
Molecular determinants of cAMP ...... expressed in human cell lines.
@en
type
label
Molecular determinants of cAMP ...... expressed in human cell lines.
@en
prefLabel
Molecular determinants of cAMP ...... expressed in human cell lines.
@en
P2093
P2860
P1476
Molecular determinants of cAMP ...... expressed in human cell lines.
@en
P2093
L Cleemann
Li-Ping He
N M Soldatov
P2860
P304
P356
10.1113/JPHYSIOL.2002.036426
P407
P577
2003-03-07T00:00:00Z