An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.
about
Mucin granule intraluminal organizationKeeping bugs in check: The mucus layer as a critical component in maintaining intestinal homeostasisCharacterization of member of DUF1888 protein family, self-cleaving and self-assembling endopeptidase.Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling HubThe rat IgGFcγBP and Muc2 C-terminal domains and TFF3 in two intestinal mucus layers bind together by covalent interactionThe two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactionsDefective goblet cell exocytosis contributes to murine cystic fibrosis-associated intestinal disease.Zonadhesin D3-polypeptides vary among species but are similar in Equus species capable of interbreedingSea star tenacity mediated by a protein that fragments, then aggregatesAltered Mucins (MUC) trafficking in benign and malignant conditions.Targeted expression, purification, and cleavage of fusion proteins from inclusion bodies in Escherichia coli.Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel.The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system.Perspectives on mucus properties and formation--lessons from the biochemical worldNegative feedback by IRE1β optimizes mucin production in goblet cells.Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).The Reduction-insensitive Bonds of the MUC2 Mucin Are Isopeptide Bonds.Management of the human mucosal defensive barrier: evidence for glycan legislation.Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer.Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein domains.Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon mucus.Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin.Mucin granule intraluminal organization in living mucous/goblet cells. Roles of protein post-translational modifications and secretion.Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells.Recycling of the membrane-anchored chemokine, CX3CL1.Processing, localization and binding activity of zonadhesin suggest a function in sperm adhesion to the zona pellucida during exocytosis of the acrosome.Assay of mucins in human tear fluid.Characterization of the self-cleaving effector protein NopE1 of Bradyrhizobium japonicum.Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning.A novel "clip-and-link" activity of repeat in toxin (RTX) proteins from gram-negative pathogens. Covalent protein cross-linking by an Asp-Lys isopeptide bond upon calcium-dependent processing at an Asp-Pro bond.pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells.
P2860
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P2860
An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.
description
2003 nî lūn-bûn
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2003年の論文
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2003年論文
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2003年論文
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2003年論文
@zh-hk
2003年論文
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2003年論文
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name
An autocatalytic cleavage in t ...... of the late secretory pathway.
@en
type
label
An autocatalytic cleavage in t ...... of the late secretory pathway.
@en
prefLabel
An autocatalytic cleavage in t ...... of the late secretory pathway.
@en
P356
P1476
An autocatalytic cleavage in t ...... of the late secretory pathway
@en
P2093
Gunnar C Hansson
Martin E Lidell
P304
13944-13951
P356
10.1074/JBC.M210069200
P407
P577
2003-02-11T00:00:00Z