Nucleosomes possess a high affinity for glomerular laminin and collagen IV and bind nephritogenic antibodies in murine lupus-like nephritis.
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Lupus nephritis: the central role of nucleosomes revealedThe Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice.Deficiency of activating Fcγ-receptors reduces hepatic clearance and deposition of IC and increases CIC levels in mercury-induced autoimmunity.Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritisAutoantibodies: Focus on anti-DNA antibodies.Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature in murine lupus nephritis.TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive FormAnti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice.Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes.LMW heparin prevents increased kidney expression of proinflammatory mediators in (NZBxNZW)F1 miceProgression of murine lupus nephritis is linked to acquired renal Dnase1 deficiency and not to up-regulated apoptosis.Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis.Glomerular antibodies in lupus nephritis.Nuclease deficiencies promote end-stage lupus nephritis but not nephritogenic autoimmunity in (NZB × NZW) F1 mice.Chromatin as a target antigen in human and murine lupus nephritisImmunity and autoimmunity to dsDNA and chromatin--the role of immunogenic DNA-binding proteins and nuclease deficiencies.Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity.The pathogenesis and diagnosis of systemic lupus erythematosus: still not resolved.The effect of cell death in the initiation of lupus nephritis.Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus.The anti-DNA antibody: origin and impact, dogmas and controversies.Clinical phenotype associations with various types of anti-dsDNA antibodies in patients with recent onset of rheumatic symptoms. Results from a multicentre observational studyCirculating chromatin-anti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis.Development of lupus nephritis is associated with qualitative changes in the glomerular collagen IV matrix composition.Heparin exerts a dual effect on murine lupus nephritis by enhancing enzymatic chromatin degradation and preventing chromatin binding in glomerular membranes.Autoantibodies in SLE: Specificities, Isotypes and Receptors
P2860
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P2860
Nucleosomes possess a high affinity for glomerular laminin and collagen IV and bind nephritogenic antibodies in murine lupus-like nephritis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Nucleosomes possess a high aff ...... n murine lupus-like nephritis.
@en
type
label
Nucleosomes possess a high aff ...... n murine lupus-like nephritis.
@en
prefLabel
Nucleosomes possess a high aff ...... n murine lupus-like nephritis.
@en
P2860
P356
P1476
Nucleosomes possess a high aff ...... n murine lupus-like nephritis.
@en
P2093
J E Mjelle
K A Fenton
P2860
P304
P356
10.1136/ARD.2007.070482
P407
P577
2007-05-15T00:00:00Z