Pregnenolone can protect the brain from cannabis intoxication. - Wikidata - awgldk - TriplyDB

Pregnenolone can protect the brain from cannabis intoxication.

Pregnenolone can protect the brain from cannabis intoxication.

http://www.wikidata.org/entity/Q40700671

about

Cannabinoid receptor type-1: breaking the dogmas Marijuana, the Endocannabinoid System and the Female Reproductive System Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments.Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.Interactions of Cannabinoids With Biochemical Substrates A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression New insights on the role of the endocannabinoid system in the regulation of energy balance.Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s).Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.Neurosteroid biosynthesis downregulation and changes in GABAA receptor subunit composition: A biomarker axis in stress-induced cognitive and emotional impairment.Reduction of circulating and selective limbic brain levels of (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) following forced swim stress in C57BL/6J mice Medical marijuana in the workplace: challenges and management options for occupational physicians Gonadal hormones do not alter the development of antinociceptive tolerance to delta-9-tetrahydrocannabinol in adult rats Ovarian hormones and drug abuse Enhancing Brain Pregnenolone May Protect Cannabis Intoxication but Should Not Be Considered as an Anti-addiction Therapeutic: Hypothesizing Dopaminergic Blockade and Promoting Anti-Reward.Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model.Pregnenolone sulfate as a modulator of synaptic plasticity.Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research.Screening Medications for the Treatment of Cannabis Use Disorder.The effects of Δ9-tetrahydrocannabinol on the dopamine system.Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease.Of cilia, titin, and neurosteroids.Structure-activity relationship studies on neuroactive steroids in memory, alcohol and stress-related functions: a crucial benefit from endogenous level analysis.Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators.The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus.Dissecting the cannabinergic control of behavior: The where matters.In silico mapping of allosteric ligand binding sites in type-1 cannabinoid receptor.The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB1 receptor allosteric modulators.Preclinical Studies of Cannabinoid Reward, Treatments for Cannabis Use Disorder, and Addiction-Related Effects of Cannabinoid Exposure.An Introduction to the Endogenous Cannabinoid System.Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence.Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target.Medical cannabis vs. synthetic cannabinoids: What does the future hold?Changes in endocannabinoid receptors and enzymes in the spinal cord of SOD1(G93A) transgenic mice and evaluation of a Sativex(®) -like combination of phytocannabinoids: interest for future therapies in amyotrophic lateral sclerosis.Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities.Cannabinoid Receptor Signaling in Central Regulation of Feeding Behavior: A Mini-Review.

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Pregnenolone can protect the brain from cannabis intoxication.

http://www.wikidata.org/entity/Q40700671

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2014 nî lūn-bûn

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2014年论文

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2014年论文

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2014年论文

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Pregnenolone can protect the brain from cannabis intoxication.

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Pregnenolone can protect the brain from cannabis intoxication.

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Pregnenolone can protect the brain from cannabis intoxication.

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Pregnenolone can protect the brain from cannabis intoxication.

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Derek M Shore

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Diane L Lynch

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Monique Vallée

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P2860

Neurosteroids in learning and memory processes

Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought

Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice.

Neurosteroids in learning and memory processes

The molecular logic of endocannabinoid signalling

International Union of Pharmacology. XXVII. Classification of cannabinoid receptors

Stress and the brain: from adaptation to disease

Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum.

Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS).

Neurosteroids: beginning of the story.

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Fernando Kasanetz

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