p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation.
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Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cellsApoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g)Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory proteinThe emerging roles of ribosome biogenesis in craniofacial developmentmTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventionsp53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signalingPondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stressExploration of the cell-cycle genes found within the RIKEN FANTOM2 data set.Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation.The coordinate regulation of the p53 and mTOR pathways in cells.Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescencePhospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of actionL-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway.mTORC1 and p53: clash of the gods?Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.Regulation of protein synthesis by ionizing radiation.Dysregulation of the mTOR pathway in p53-deficient mice.p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.Translation initiation: a critical signalling node in cancer.CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis.Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signalingmTORC1 signaling: what we still don't know.Anti-oncogenic potential of the eIF4E-binding proteins.p53, a translational regulator: contribution to its tumour-suppressor activity.Regulation of translation factors eIF4GI and 4E-BP1 during recovery of protein synthesis from inhibition by p53.Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas.Physical and functional interaction of the p14ARF tumor suppressor with ribosomes.Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.PKR, a cognitive decline biomarker, can regulate translation via two consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients.Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53.The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming.Translation Control by p53.40 Years of Research Put p53 in Translation.Biological Aspects of mTOR in Leukemia
P2860
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P2860
p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
p53 activation results in rapi ...... ion of translation initiation.
@en
type
label
p53 activation results in rapi ...... ion of translation initiation.
@en
prefLabel
p53 activation results in rapi ...... ion of translation initiation.
@en
P2093
P2860
P356
P1433
P1476
p53 activation results in rapi ...... ion of translation initiation.
@en
P2093
Diane Barth-Baus
Jack O Hensold
Lynn E Horton
Martin Bushell
Michael J Clemens
Vivienne J Tilleray
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205662
P407
P577
2002-08-01T00:00:00Z
P5875
P6179
1043146657