Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.
about
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycleRegulation of AMP-activated protein kinase by natural and synthetic activatorsTherapeutic Use of Metformin in Prediabetes and Diabetes PreventionRole of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacologyProton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer CellsMembrane transporters in drug developmentMembrane transporters as mediators of Cisplatin effects and side effects.Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.Metformin and respiratory chain complex I: the last piece of the puzzle?Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.Metformin increases plasma ghrelin in Type 2 diabetes.Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Pharmacokinetics of metformin during pregnancy.Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation.OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.Pharmacogenetics of Anti-Diabetes Drugs.Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.Cardiovascular impact of drugs used in the treatment of diabetesOCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects.Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium.Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice.Verapamil decreases the glucose-lowering effect of metformin in healthy volunteersPharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.Metformin and erlotinib synergize to inhibit basal breast cancer.Proton pump inhibitors do not impair the effectiveness of metformin in patients with diabetes.Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 geneMetformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy statusThe physiological role of drug transporters.Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metforminEffect of genetic variation in the organic cation transporter 1 (OCT1) on metformin actionPharmacogenetics of metformin response: a step in the path toward personalized medicineGlobal genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1.Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human LiverMechanism of Altered Metformin Distribution in Nonalcoholic SteatohepatitisDeficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cationsMechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.
P2860
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P2860
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Involvement of organic cation ...... nal distribution of metformin.
@en
type
label
Involvement of organic cation ...... nal distribution of metformin.
@en
prefLabel
Involvement of organic cation ...... nal distribution of metformin.
@en
P2093
P356
P1476
Involvement of organic cation ...... nal distribution of metformin.
@en
P2093
Alfred H Schinkel
De-Sheng Wang
Hiroyuki Kusuhara
Yuichi Sugiyama
Yukio Kato
P304
P356
10.1124/JPET.102.034140
P407
P577
2002-08-01T00:00:00Z