A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death
about
Dual interaction of the Hsp70 J-protein cochaperone Zuotin with the 40S and 60S ribosomal subunitsTouch and go: nuclear proteolysis in the regulation of metabolic genes and cancerSending Out an SOS: Mitochondria as a Signaling HubAlleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegenerationPINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease.Control of mitochondrial biogenesis and function by the ubiquitin-proteasome systemStress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS productionProtein homeostasis of a metastable subproteome associated with Alzheimer's disease.Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA.Engineering microbial phenotypes through rewiring of genetic networks.The Mitochondrial Basis of Aging.Metabolism and the UPR(mt).How do yeast sense mitochondrial dysfunction?Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.Ground control to major TOM: mitochondria-nucleus communication.Mitochondrial translation and cellular stress response.Integrating the UPRmt into the mitochondrial maintenance network.Non-coding RNAs: the dark side of nuclear-mitochondrial communication.CLIC, a tool for expanding biological pathways based on co-expression across thousands of datasets.Cellular growth defects triggered by an overload of protein localization processes.MCbiclust: a novel algorithm to discover large-scale functionally related gene sets from massive transcriptomics data collectionsUbiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.Mammalian ataxin-2 modulates translation control at the pre-initiation complex via PI3K/mTOR and is induced by starvation.The mitochondrial UPR: mechanisms, physiological functions and implications in ageing.Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging.Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins.mPOS is a novel mitochondrial trigger of cell death - implications for neurodegeneration.The mitochondrion: a central architect of copper homeostasis.Proteolytic cleavage by the inner membrane peptidase (IMP) complex or Oct1 peptidase controls the localization of the yeast peroxiredoxin Prx1 to distinct mitochondrial compartments.Mitochondrial retrograde signaling in the nervous system.Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.Hsp70 at the membrane: driving protein translocation.Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases.UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication.The mitochondrial unfolded protein response: Signaling from the powerhouse.Escorted by chaperones: Sti1 helps to usher precursor proteins from the ribosome to mitochondria.Cell biology: Surviving import failure.Sensing the Stress: A Role for the UPRmt and UPRam in the Quality Control of Mitochondria.
P2860
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P2860
A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death
@en
type
label
A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death
@en
prefLabel
A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death
@en
P2860
P356
P1433
P1476
A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death
@en
P2093
Xiaowen Wang
Xin Jie Chen
P2860
P2888
P304
P356
10.1038/NATURE14859
P407
P577
2015-07-20T00:00:00Z
P6179
1051541254