High order chromatin architecture shapes the landscape of chromosomal alterations in cancer.
about
Pairing and anti-pairing: a balancing act in the diploid genomeNext-Generation Sequencing Approaches in Cancer: Where Have They Brought Us and Where Will They Take Us?Analysis methods for studying the 3D architecture of the genomeAn Overview of Genome Organization and How We Got There: from FISH to Hi-CComplex correlations: replication timing and mutational landscapes during cancer and genome evolutionFunctional genomics lead to new therapies in follicular lymphomaStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewFractal dimension of chromatin: potential molecular diagnostic applications for cancer prognosisLung cancer-a fractal viewpoint.Cancer genome sequencing: understanding malignancy as a disease of the genome, its conformation, and its evolution.Effect of nuclear architecture on the efficiency of double-strand break repair.Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumoursUnderstanding spatial organizations of chromosomes via statistical analysis of Hi-C dataEvolution of the cancer genomeAn independent genome duplication inferred from Hox paralogs in the American paddlefish--a representative basal ray-finned fish and important comparative referenceThe Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene ExpressionStatistical confidence estimation for Hi-C data reveals regulatory chromatin contactsHandling realistic assumptions in hypothesis testing of 3D co-localization of genomic elements.Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopyGraph rigidity reveals well-constrained regions of chromosome conformation embeddings.Deconvolution of Ensemble Chromatin Interaction Data Reveals the Latent Mixing Structures in Cell SubpopulationsA computational strategy to adjust for copy number in tumor Hi-C data.Chromosomal dynamics predicted by an elastic network model explains genome-wide accessibility and long-range couplingsIdentification of alternative topological domains in chromatin.Organization of the mitotic chromosome.Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics.Medicine. Combating evolution to fight disease.The Alu-rich genomic architecture of SPAST predisposes to diverse and functionally distinct disease-associated CNV alleles.Absolute quantification of somatic DNA alterations in human cancerEstrogen induces global reorganization of chromatin structure in human breast cancer cellsInvestigation of nanoscale structural alterations of cell nucleus as an early sign of cancer.Microsatellite stable colorectal cancers stratified by the BRAF V600E mutation show distinct patterns of chromosomal instability.Histone modifications are associated with transcript isoform diversity in normal and cancer cellsClonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasisA streamlined tethered chromosome conformation capture protocol.Mechanisms for recurrent and complex human genomic rearrangements.Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer TypesCancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the hostOncogenic transcription factors as master regulators of chromatin topology: a new role for ERG in prostate cancerMolecular characteristics and chromatin texture features in acute promyelocytic leukemia.
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P2860
High order chromatin architecture shapes the landscape of chromosomal alterations in cancer.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
High order chromatin architect ...... mosomal alterations in cancer.
@en
type
label
High order chromatin architect ...... mosomal alterations in cancer.
@en
prefLabel
High order chromatin architect ...... mosomal alterations in cancer.
@en
P2860
P356
P1433
P1476
High order chromatin architect ...... mosomal alterations in cancer.
@en
P2093
Geoff Fudenberg
Leonid A Mirny
P2860
P2888
P304
P356
10.1038/NBT.2049
P577
2011-11-20T00:00:00Z
P5875
P6179
1003051025