Elimination of P1 arginine 393 interaction with underlying glutamic acid 255 partially activates antithrombin III for thrombin inhibition but not factor Xa inhibition.
about
Inhibitory properties of the P1 Tyr variant of antithrombin.Antithrombin III deficiency in Indian patients with deep vein thrombosis: identification of first India based AT variants including a novel point mutation (T280A) that leads to aggregation.Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization.Role of P2 glycine in determining the specificity of antithrombin reaction with coagulation proteases.Comparison of biological activities of human antithrombins with high-mannose or complex-type nonfucosylated N-linked oligosaccharides.Antithrombin III phenylalanines 122 and 121 contribute to its high affinity for heparin and its conformational activation.Localization of an antithrombin exosite that promotes rapid inhibition of factors Xa and IXa dependent on heparin activation of the serpin.Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa.
P2860
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P2860
Elimination of P1 arginine 393 interaction with underlying glutamic acid 255 partially activates antithrombin III for thrombin inhibition but not factor Xa inhibition.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Elimination of P1 arginine 393 ...... but not factor Xa inhibition.
@en
type
label
Elimination of P1 arginine 393 ...... but not factor Xa inhibition.
@en
prefLabel
Elimination of P1 arginine 393 ...... but not factor Xa inhibition.
@en
P2093
P2860
P356
P1476
Elimination of P1 arginine 393 ...... but not factor Xa inhibition.
@en
P2093
Mohamad Aman Jairajpuri
Susan C Bock
P2860
P304
24460-24465
P356
10.1074/JBC.M203127200
P407
P577
2002-04-23T00:00:00Z