The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells.
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Primitive hematopoietic cells resist HIV-1 infection via p21The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytesSynthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization.Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma.Proteomic analysis shows synthetic oleanane triterpenoid binds to mTORTriterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound.Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms.Chemotherapeutic approaches for targeting cell death pathways.Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agentsMaslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells.The synthetic triterpenoid, CDDO, suppresses alloreactive T cell responses and reduces murine early acute graft-versus-host disease mortality.Targeting signalling pathways for the treatment of multiple myeloma.Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adductRole of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignanciesCDDO-imidazolide mediated inhibition of malignant cell growth in Waldenström macroglobulinemiaEffects of PPARγ Ligands on Leukemia.Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells.Synthetic triterpenoid cyano enone of methyl boswellate activates intrinsic, extrinsic, and endoplasmic reticulum stress cell death pathways in tumor cell lines.Maslinic acid induces apoptosis in salivary gland adenoid cystic carcinoma cells by Ca2+-evoked p38 signaling pathway.Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia.(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells.Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO).Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutationThe novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells.The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis.
P2860
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P2860
The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
The novel triterpenoid 2-cyano ...... actor in human leukemia cells.
@en
type
label
The novel triterpenoid 2-cyano ...... actor in human leukemia cells.
@en
prefLabel
The novel triterpenoid 2-cyano ...... actor in human leukemia cells.
@en
P2093
P356
P1476
The novel triterpenoid 2-cyano ...... actor in human leukemia cells.
@en
P2093
Alan Eastman
Michael B Sporn
Nanjoo Suh
Neema Ganju
Terrance A Stadheim
P304
16448-16455
P356
10.1074/JBC.M108974200
P407
P577
2002-03-05T00:00:00Z