Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction.
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Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activityIdentification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cellsNegative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes.Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophagesConcerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motilityCrystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2Inhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs)The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 cateninExpression of protein-tyrosine phosphatases in the major insulin target tissuesOncogenic mechanisms of the Helicobacter pylori CagA proteinPhosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signalingShp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiationAssociation of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumor cells. Phosphatidic acid activates receptor dephosphorylation by PTP1CThe protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31)Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathwayDifferential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signalingActivation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expressionControlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimersAssociation between receptor protein-tyrosine phosphatase RPTPalpha and the Grb2 adaptor. Dual Src homology (SH) 2/SH3 domain requirement and functional consequences.SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsHCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.Control of oligodendrocyte generation and proliferation by Shp2 protein tyrosine phosphatase.Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells.Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factorMolecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity.Gbeta gamma -independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase.Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase.Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment.Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals.Functions of Shp2 in cancer.Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells.Shp2 as a therapeutic target for leptin resistance and obesity.SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer.Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway.A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development.
P2860
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P2860
Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction.
@en
type
label
Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction.
@en
prefLabel
Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction.
@en
P1433
P1476
Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction.
@en
P2093
P356
10.1016/0168-9525(94)90149-X
P577
1994-02-01T00:00:00Z