A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells.
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The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenanceTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationTelomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeatsShelterin complex and associated factors at human telomeresTelomere shortening in human diseasesMRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length controlRole of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damageTelomeres, early-life stress and mental illnessTrf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells.Identification of differentially expressed genes in mouse hepatocarcinoma ascites cell line with low potential of lymphogenous metastasis.Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenancePinX1: a sought-after major tumor suppressor at human chromosome 8p23Targeted deletion reveals an essential function for the telomere length regulator Trf1.Shelterin Protects Chromosome Ends by Compacting Telomeric ChromatinATM regulates the length of individual telomere tracts in ArabidopsisTelomeres, histone code, and DNA damage response.Zebrafish as a model system to screen radiation modifiers.Mitotic perturbations induced by Nek2 overexpression require interaction with TRF1 in breast cancer cells.Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease.Telomeres and human health.DNA damage transiently increases TRF2 mRNA expression and telomerase activity.Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation.Protection of internal (TTAGGG)n repeats in Chinese hamster cells by telomeric protein TRF1.Genetic profile and biological implication of PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) in human cancers: an analysis using The Cancer Genome Atlas.Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish.Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging.
P2860
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P2860
A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
A critical role for Pin2/TRF1 ...... f ataxia-telangiectasia cells.
@en
type
label
A critical role for Pin2/TRF1 ...... f ataxia-telangiectasia cells.
@en
prefLabel
A critical role for Pin2/TRF1 ...... f ataxia-telangiectasia cells.
@en
P2860
P356
P1476
A critical role for Pin2/TRF1 ...... f ataxia-telangiectasia cells.
@en
P2093
Kun Ping Lu
Shuji Kishi
P2860
P304
P356
10.1074/JBC.M111365200
P407
P577
2001-12-13T00:00:00Z