BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.
about
ABL tyrosine kinases: evolution of function, regulation, and specificityEvidence for a direct involvement of hMSH5 in promoting ionizing radiation induced apoptosisTyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding.Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distributionConstitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation.Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancerEnhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cellsNucleases in homologous recombination as targets for cancer therapyTargeting DNA damage response in cancer therapyInhibition of c-Abl kinase activity renders cancer cells highly sensitive to mitoxantroneProtective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiationc-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated LeukemiasThe consequences of Rad51 overexpression for normal and tumor cellsPersonalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.Increased RPA1 gene dosage affects genomic stability potentially contributing to 17p13.3 duplication syndromeThe Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination PhenotypeBCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death thresholdSH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway.Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia.The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability.Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.BCR-ABL stimulates mutagenic homologous DNA double-strand break repair via the DNA-end-processing factor CtIP.Is homologous recombination really an error-free process?BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells.Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.Taking a Bad Turn: Compromised DNA Damage Response in LeukemiaRegulation of Rad51 promoter.Chronic myeloid leukemia: mechanisms of blastic transformationBerberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51Experimental approaches for the treatment of malignant gliomas.RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cellsFusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis.An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.Rad51 regulates cell cycle progression by preserving G2/M transition in mouse embryonic stem cells.Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps.Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damageBiochemistry of eukaryotic homologous recombination.
P2860
Q24299738-17DF3FE9-A0E4-4D96-8687-390DCCD814F5Q24310554-065ED74C-71D3-423E-AD2D-B3C5CD8B038FQ24318110-7C49F172-D7AE-4CCC-B2A9-960E981FFF45Q24318820-4E0F261D-57C0-4FDB-85E0-AF8661EDFE7FQ24537451-76481048-B66B-4DD0-9CF4-31DA9621D1EEQ24647338-17238309-EF55-466D-80DB-202DAD3A7E2DQ24670609-55AD96A8-449A-41BD-BC67-2F6C2A99066CQ26822478-A8FCDF0C-3F86-4951-804B-A5BC49412D20Q27023204-941D5E72-26A3-4564-9908-914439C23DFEQ27313997-3AEABB78-7F38-41CD-8DBC-06574FBEEDE2Q28235715-652A1568-4C8C-4E95-A698-79D1B6952DA4Q28259732-3469B6A7-4FD6-4D16-A657-597A199CAB0DQ28266986-F323040D-BAA1-4166-B95A-14D318EDF08FQ28294205-513CC03C-92F5-43F5-A5ED-8559BC671FC2Q28476701-8B61F78F-4690-4B55-B0DD-86A79F99ACE4Q28553470-AFE3E166-147A-4B41-984B-34390AE64553Q28704493-C9946A58-1350-4D0F-A13F-F1158918318EQ30008841-47BCD5A8-478D-4F9D-A13F-ED214645E305Q30010486-9591BCC7-4290-4433-91C5-CC55114D3F6DQ30165112-AF834CDC-C98D-4C31-9D14-C342E0D9F77EQ30537656-6BDEB553-DC02-47E4-A845-40A8B596E7DBQ30922231-5FFDE8B5-D43F-47C5-8C1C-BF7076FE4FBDQ33425105-38C426C5-610D-41FC-9A1D-8947FDC61F9EQ33727572-5CFB2650-0921-4584-8D87-477AF69D1224Q33736829-9C508B50-B9AE-43E0-BD15-A3A3C20DDD33Q33796384-FB61950F-B11B-4DB2-A70F-CE661C44DA38Q33802540-A3F53DC0-4466-453F-961F-190425CF4951Q33838509-0D73D2E3-711F-4952-B5B0-E429DE8CC85CQ33855938-E49A4541-0BD3-42EC-B51D-E3F2983A81B9Q33952859-10E9D9DF-FE20-45FB-8BE3-2227C9C1391AQ33968037-994FE159-2B09-40EC-8179-6DDEA6650BFAQ33999614-1CC3E5C9-ED9B-4871-B709-AD7B069333CFQ34127138-8D82412C-DD1F-48B5-9706-8D113C72FE42Q34273832-380319A1-21B4-4527-AD83-FF01F3BAFE32Q34281241-DFD63F55-BD2B-4467-8A50-4AFE37EC65A1Q34316998-2BEC1326-124E-48CA-8F03-B4874031431DQ34437223-723A5B78-1372-4E6D-914F-C2E494F96896Q34671726-0B7361C9-DD82-428F-9E0F-D7ADA4C650EFQ34718035-2A7A143F-D0C2-4EA8-B970-1FD07EF03EDAQ34925302-8F8DE7C0-177D-4DE4-AE9C-BF9412AE1820
P2860
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.
@en
type
label
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.
@en
prefLabel
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.
@en
P2093
P1433
P1476
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.
@en
P2093
Nieborowska-Skorska M
Nowicki MO
Schmutte C
Slupianek A
Tombline G
P304
P356
10.1016/S1097-2765(01)00357-4
P577
2001-10-01T00:00:00Z