Mechanism of the inhibition of protein synthesis by kirromycin. Role of elongation factor Tu and ribosomes.
about
tRNAs as antibiotic targetssmFRET studies of the 'encounter' complexes and subsequent intermediate states that regulate the selectivity of ligand bindingConformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding. Crystal structure of the complex between EF-Tu.GDP and aurodoxCryo-EM reveals an active role for aminoacyl-tRNA in the accommodation processIncorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopyAntibiotics of the virginiamycin family, inhibitors which contain synergistic components.Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation.Structure and dynamics of a processive Brownian motor: the translating ribosomeProtein synthesis elongation factors Tu and Tu.Ts from Caulobacter crescentus: sensitivity to kirromycin and activity in Q beta replicase.The elongation factor EF-Tu from E. coli binds to the upstream activator region of the tRNA-tufB operonInhibition of translation by cytotrienin A--a member of the ansamycin familyIdentification of an mRNP complex regulating tumorigenesis at the translational elongation stepAntimicrobial growth promoters used in animal feed: effects of less well known antibiotics on gram-positive bacteria.Elongation factor Tu resistant to kirromycin in an Escherichia coli mutant altered in both tuf genesEffects of elfamycins on elongation factor Tu from Escherichia coli and Staphylococcus aureus.Interaction of Mycobacterium tuberculosis elongation factor Tu with GTP is regulated by phosphorylation.Protein synthesis during cellular quiescence is inhibited by phosphorylation of a translational elongation factor.Enacyloxin IIa, an inhibitor of protein biosynthesis that acts on elongation factor Tu and the ribosome.Mutants of Escherichia coli altered in both genes coding for the elongation factor Tu.Mutant ribosomes can generate dominant kirromycin resistanceCross-linking of tRNA at two different sites of the elongation factor Tu.Elongation factor Tu isolated from Escherichia coli mutants altered in TufA and tufB.Effect of inhibitors of elongation factor Tu on the metabolic regulation of protein synthesis in Escherichia coliGenetic and biochemical characterization of kirromycin resistance mutations in Bacillus subtilisA 1H NMR study of the Escherichia coli elongation-factor Tu with guanine nucleotides and the antibiotic kirromycin.tRNA-ribosome interactions.Pulvomycin, an inhibitor of protein biosynthesis preventing ternary complex formation between elongation factor Tu, GTP, and aminoacyl-tRNA.Asparagine-135 of elongation factor Tu is a crucial residue for the folding of the guanine nucleotide binding pocket.Biosynthesis of polyketides by trans-AT polyketide synthases.Stop making sense: or Regulation at the level of termination in eukaryotic protein synthesis.A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome.Differential susceptibilities of enterococcal species to elfamycin antibiotics.Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII.Isolation and stability of ternary complexes of elongation factor Tu, GTP and aminoacyl-tRNA.Pulvomycin-resistant mutants of E.coli elongation factor Tu.Codon-dependent conformational change of elongation factor Tu preceding GTP hydrolysis on the ribosome.Isolation and characterization of a mocimycin resistant mutant of Escherichia coli with an altered elongation factor EF-Tu.Hydrolysis of GTP by the elongation factor Tu.kirromycin complex. Specific action of monovalent cations.The elongation factor Tu.kirromycin complex has two binding sites for tRNA molecules.Specific alterations of the EF-Tu polypeptide chain considered in the light of its three-dimensional structure.
P2860
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P2860
Mechanism of the inhibition of protein synthesis by kirromycin. Role of elongation factor Tu and ribosomes.
description
1977 nî lūn-bûn
@nan
1977年の論文
@ja
1977年学术文章
@wuu
1977年学术文章
@zh-cn
1977年学术文章
@zh-hans
1977年学术文章
@zh-my
1977年学术文章
@zh-sg
1977年學術文章
@yue
1977年學術文章
@zh
1977年學術文章
@zh-hant
name
Mechanism of the inhibition of ...... ation factor Tu and ribosomes.
@en
type
label
Mechanism of the inhibition of ...... ation factor Tu and ribosomes.
@en
prefLabel
Mechanism of the inhibition of ...... ation factor Tu and ribosomes.
@en
P2093
P1433
P1476
Mechanism of the inhibition of ...... ation factor Tu and ribosomes.
@en
P2093
P356
10.1111/J.1432-1033.1977.TB11504.X
P407
P577
1977-05-01T00:00:00Z