Inflammation promotes the loss of adeno-associated virus-mediated transgene expression in mouse liver.
about
Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions.In vivo evaluation of adeno-associated virus gene transfer in airways of mice with acute or chronic respiratory infection.Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9Intramuscular injection of AAV8 in mice and macaques is associated with substantial hepatic targeting and transgene expression.Examining the cross-reactivity and neutralization mechanisms of a panel of mAbs against adeno-associated virus serotypes 1 and 5.The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing.Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.Extracorporeal delivery of rAAV with metabolic exchange and oxygenationIL12-mediated liver inflammation reduces the formation of AAV transcriptionally active forms but has no effect over preexisting AAV transgene expression.Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system miceAAV vectors expressing LDLR gain-of-function variants demonstrate increased efficacy in mouse models of familial hypercholesterolemia.In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV.
P2860
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P2860
Inflammation promotes the loss of adeno-associated virus-mediated transgene expression in mouse liver.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
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2011年學術文章
@zh-hant
name
Inflammation promotes the loss ...... ene expression in mouse liver.
@en
type
label
Inflammation promotes the loss ...... ene expression in mouse liver.
@en
prefLabel
Inflammation promotes the loss ...... ene expression in mouse liver.
@en
P2093
P2860
P1433
P1476
Inflammation promotes the loss ...... gene expression in mouse liver
@en
P2093
Ekaterina Breous
Peter Bell
Suryanarayan Somanathan
P2860
P304
348-57, 357.e1-3
P356
10.1053/J.GASTRO.2011.04.002
P407
P577
2011-04-12T00:00:00Z