Functional analysis of hepatitis C virus E2 glycoproteins and virus-like particles reveals structural dissimilarities between different forms of E2.
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Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domainsInfectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexesAssembly and release of infectious hepatitis C virus involving unusual organization of the secretory pathwayHepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcriptionHuman serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infectionAn Interplay between Hypervariable Region 1 of the Hepatitis C Virus E2 Glycoprotein, the Scavenger Receptor BI, and High-Density Lipoprotein Promotes both Enhancement of Infection and Protection against Neutralizing AntibodiesMonoclonal Antibody AP33 Defines a Broadly Neutralizing Epitope on the Hepatitis C Virus E2 Envelope GlycoproteinBasic residues in hypervariable region 1 of hepatitis C virus envelope glycoprotein e2 contribute to virus entry.Analysis of antigenicity and topology of E2 glycoprotein present on recombinant hepatitis C virus-like particles.Interaction of hepatitis C virus-like particles and cells: a model system for studying viral binding and entry.Identification of the hepatitis C virus E2 glycoprotein binding site on the large extracellular loop of CD81Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes.Recognition of native hepatitis C virus E1E2 heterodimers by a human monoclonal antibody.Different Domains of CD81 Mediate Distinct Stages of Hepatitis C Virus Pseudoparticle EntryComplement-mediated enhancement of antibody function for neutralization of pseudotype virus containing hepatitis C virus E2 chimeric glycoproteinA Conserved Gly436-Trp-Leu-Ala-Gly-Leu-Phe-Tyr Motif in Hepatitis C Virus Glycoprotein E2 Is a Determinant of CD81 Binding and Viral EntryIdentification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 BindingCharacterization of the genome and structural proteins of hepatitis C virus resolved from infected human liverA focus reduction neutralization assay for hepatitis C virus neutralizing antibodiesHepatitis C Virus Envelope Glycoprotein E2 Glycans Modulate Entry, CD81 Binding, and NeutralizationCharacterization of Fusion Determinants Points to the Involvement of Three Discrete Regions of Both E1 and E2 Glycoproteins in the Membrane Fusion Process of Hepatitis C VirusHuman combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virusDissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: Putative CD81 binding region 1 is not involved in CD81 bindingCD81-Dependent Binding of Hepatitis C Virus E1E2 HeterodimersEfficient trans-Encapsidation of Hepatitis C Virus RNAs into Infectious Virus-Like ParticlesIn vitro selection of a neutralization-resistant hepatitis C virus escape mutantHepatitis C Virus (HCV) Infection May Elicit Neutralizing Antibodies Targeting Epitopes Conserved in All Viral GenotypesMouse-Specific Residues of Claudin-1 Limit Hepatitis C Virus Genotype 2a Infection in a Human Hepatocyte Cell LineStructure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33Toward a Hepatitis C Virus Vaccine: the Structural Basis of Hepatitis C Virus Neutralization by AP33, a Broadly Neutralizing AntibodyA novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits Hepatitis C virus cell-cell transmissionNaturally occurring antibodies that recognize linear epitopes in the amino terminus of the hepatitis C virus E2 protein confer noninterfering, additive neutralizationBinding of the hepatitis C virus E2 glycoprotein to CD81 is strain specific and is modulated by a complex interplay between hypervariable regions 1 and 2.Unexpected structural features of the hepatitis C virus envelope protein 2 ectodomain.HCV infection of the transplanted liver: changing CD81 and HVR1 variants immediately after liver transplantation.Inhibition of hepatitis C virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C.Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33.Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors.A Sequence in the loop domain of hepatitis C virus E2 protein identified in silico as crucial for the selective binding to human CD81.Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2.
P2860
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P2860
Functional analysis of hepatitis C virus E2 glycoproteins and virus-like particles reveals structural dissimilarities between different forms of E2.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Functional analysis of hepatit ...... between different forms of E2.
@en
type
label
Functional analysis of hepatit ...... between different forms of E2.
@en
prefLabel
Functional analysis of hepatit ...... between different forms of E2.
@en
P2093
P1476
Functional analysis of hepatit ...... between different forms of E2.
@en
P2093
Clayton RF
Loomis-Price LD
McKeating JA
Owsianka A
P304
P356
10.1099/0022-1317-82-8-1877
P407
P577
2001-08-01T00:00:00Z