Use-dependent block of cardiac late Na(+) current by ranolazine.
about
Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillationProton-dependent inhibition of the cardiac sodium channel Nav1.5 by ranolazineSimulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failureSuppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels.Late cardiac sodium current can be assessed using automated patch-clampElectrophysiologic basis for the antiarrhythmic actions of ranolazine.Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: I. Experimental analysis of the use-dependent blockMechanisms of atrial-selective block of Na⁺ channels by ranolazine: II. Insights from a mathematical modelQuantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk.CaMKII-dependent activation of late INa contributes to cellular arrhythmia in a model of the cardiac myocyte.Role of late sodium channel current block in the management of atrial fibrillation.Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neuronsThe Effects of Ranolazine on Paroxysmal Atrial Fibrillation in Patients with Coronary Artery Disease: A Preliminary Observational Study.Early somatic mosaicism is a rare cause of long-QT syndrome.In silico assessment of drug safety in human heart applied to late sodium current blockersRanolazine: an antianginal drug with antiarrhythmic properties.Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes.Cardiac sodium channels and inherited electrophysiological disorders: an update on the pharmacotherapy.Ranolazine as a promising treatment option for atrial fibrillation: electrophysiologic mechanisms, experimental evidence, and clinical implications.Novel ion channel targets in atrial fibrillation.Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells.Nondystrophic myotonia: challenges and future directions.The Use of Ratiometric Fluorescence Measurements of the Voltage Sensitive Dye Di-4-ANEPPS to Examine Action Potential Characteristics and Drug Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations.Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action.Dynamics and sensitivity analysis of high-frequency conduction block.Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytesRanolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants.Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: Basis for atrial-selective block by ranolazine.Ranolazine-induced postrepolarization refractoriness suppresses induction of atrial flutter and fibrillation in anesthetized rabbits.The efficacy of Ranolazine on E1784K is altered by temperature and calcium.Further insights into the underlying electrophysiological mechanisms for reduction of atrial fibrillation by ranolazine in an experimental model of chronic heart failure.
P2860
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P2860
Use-dependent block of cardiac late Na(+) current by ranolazine.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Use-dependent block of cardiac late Na(+) current by ranolazine.
@en
type
label
Use-dependent block of cardiac late Na(+) current by ranolazine.
@en
prefLabel
Use-dependent block of cardiac late Na(+) current by ranolazine.
@en
P2093
P2860
P1433
P1476
Use-dependent block of cardiac late Na(+) current by ranolazine.
@en
P2093
John C Shryock
Jonathan C Makielski
Luiz Belardinelli
Nesrine El-Bizri
Sridharan Rajamani
P2860
P304
P356
10.1016/J.HRTHM.2009.07.042
P577
2009-07-28T00:00:00Z