Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line.
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Science review: role of coagulation protease cascades in sepsisBench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsisCharacterization of protein C receptor expression in monocytesThe normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illnessAlterations in the human lung proteome with lipopolysaccharide.Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction.Refining anti-inflammatory therapy strategies for bronchopulmonary dysplasia.Transcriptome analysis revealed unique genes as targets for the anti-inflammatory action of activated protein C in human macrophages.Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory studyThe protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implicationsA phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome.Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy.Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells.Pharmacotherapy of acute respiratory distress syndrome.Renal and urinary levels of endothelial protein C receptor correlate with acute renal allograft rejection.Drotrecogin alfa: a new approach in the treatment of severe sepsis.New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins.Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitisPharmacology, clinical efficacy, and safety of drotrecogin alfa (activated).Protein C pathway in sepsis.Management of septic shock.A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture modelInflammation and thrombosis.Tissue factor, blood coagulation, and beyond: an overview.Study of osteoarthritis treatment with anti-inflammatory drugs: cyclooxygenase-2 inhibitor and steroids.Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury.Coagulation, inflammation, and the risk of neonatal white matter damage.Regulation of inflammatory responses by activated protein C: the molecular mechanism(s) and therapeutic implications.Retinoic acid and tumor necrosis factor-α induced monocytic cell gene expression is regulated in part by induction of transcription factor MafB.Microcirculatory alterations in ischemia-reperfusion injury and sepsis: effects of activated protein C and thrombin inhibition.New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated).Effects of recombinant human activated protein C in human models of endotoxin administrationActivated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66ShcDrotrecogin alfa (activated) in the treatment of severe sepsis.Recombinant activated protein C in sepsis: endothelium protection or endothelium therapy?Effects of anticoagulant strategies on activation of inflammation and coagulation.Drotrecogin alpha (activated): the treatment for severe sepsis?Recombinant human activated protein C: current insights into its mechanism of actionDissociation of activated protein C functions by elimination of protein S cofactor enhancement.Severe congenital protein C deficiency: the use of protein C concentrates (human) as replacement therapy for life-threatening blood-clotting complications
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P2860
Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Activated protein C inhibits l ...... the THP-1 monocytic cell line.
@en
type
label
Activated protein C inhibits l ...... the THP-1 monocytic cell line.
@en
prefLabel
Activated protein C inhibits l ...... the THP-1 monocytic cell line.
@en
P2093
P1476
Activated protein C inhibits l ...... the THP-1 monocytic cell line.
@en
P2093
Kelleher D
Livingstone W
Schwarz HP
P304
P356
10.1046/J.1365-2141.2000.02128.X
P407
P577
2000-07-01T00:00:00Z