The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity.
about
Variant base excision repair proteins: contributors to genomic instabilityHMGB1 is a cofactor in mammalian base excision repairKu is a 5'-dRP/AP lyase that excises nucleotide damage near broken endsHMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapyThe human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactionsDNA polymerase family X: function, structure, and cellular rolesIntrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repairA mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repairCoordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase betaInterplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cellsThe accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cellsAPE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instabilityThe "new" genetics and mammalian cloning in environmental health research.The Response to Oxidative DNA Damage in Neurons: Mechanisms and DiseaseNew perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseasesBase excision repair and cancerAag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dGUncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1).DNA polymerase beta gene expression: the promoter activator CREB-1 is upregulated in Chinese hamster ovary cells by DNA alkylating agent-induced stressSubstrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activityIdentification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repairDNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblastsBase excision repair facilitates a functional relationship between Guanine oxidation and histone demethylationHuman DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNADNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extractsA quantitative model of human DNA base excision repair. I. Mechanistic insights.Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesisIn situ analysis of repair processes for oxidative DNA damage in mammalian cells.Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: towards the design of higher-affinity inhibitors.Characterization of DNA glycosylase activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Gastrointestinal hyperplasia with altered expression of DNA polymerase beta.DNA polymerase β contains a functional nuclear localization signal at its N-terminus.Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage.FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells.Excision of a lyase-resistant oxidized abasic lesion from DNA.Inhibition of human DNA polymerase beta activity by the anticancer prodrug Cloretazine.Pol β associated complex and base excision repair factors in mouse fibroblasts.Base excision repair defects invoke hypersensitivity to PARP inhibition.
P2860
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P2860
The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
The lyase activity of the DNA ...... A-damage-induced cytotoxicity.
@en
type
label
The lyase activity of the DNA ...... A-damage-induced cytotoxicity.
@en
prefLabel
The lyase activity of the DNA ...... A-damage-induced cytotoxicity.
@en
P2093
P356
P1433
P1476
The lyase activity of the DNA ...... A-damage-induced cytotoxicity.
@en
P2093
P2888
P304
P356
10.1038/35015598
P407
P577
2000-06-01T00:00:00Z
P6179
1011677779