The alpha 1 beta 1 integrin recognition site of the basement membrane collagen molecule [alpha 1(IV)]2 alpha 2(IV).
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Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectinMammalian collagen IVType IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loopCrucial role of the CB3-region of collagen IV in PARF-induced acute rheumatic fever.Glycosylation modulates melanoma cell α2β1 and α3β1 integrin interactions with type IV collagenNew functional roles for non-collagenous domains of basement membrane collagensGlucose autoxidation induces functional damage to proteins via modification of critical arginine residuesEnhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis.Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV networkMapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes.Self-assembling peptides for stem cell and tissue engineering.Targeted drug delivery utilizing protein-like molecular architecture.Designed triple-helical peptides as tools for collagen biochemistry and matrix engineering.Extracellular chloride signals collagen IV network assembly during basement membrane formationAdvanced glycation of the Arg-Gly-Asp (RGD) tripeptide motif modulates retinal microvascular endothelial cell dysfunctionIdentification of the endothelial cell binding site for factor IX.Synthesis and biological applications of collagen-model triple-helical peptides.The glomerular basement membrane.Redox-relevant aspects of the extracellular matrix and its cellular contacts via integrinsMapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin α1β1 using collagen toolkits II and III.Unique charge-dependent constraint on collagen recognition by integrin α10β1.Plumieribetin, a fish lectin homologous to mannose-binding B-type lectins, inhibits the collagen-binding alpha1beta1 integrin.Autoantibodies against basement membrane collagen type IV are associated with myocardial infarction.Biochemical alterations in collagen IV induced by in vitro glycation.Phagocytosis and remodeling of collagen matricesInteraction of the collagen-like tail of asymmetric acetylcholinesterase with heparin depends on triple-helical conformation, sequence and stability.Integrin alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-independent platelet reactivityMetallic nanoparticles reduce the migration of human fibroblasts in vitroWhy cellular stress suppresses adipogenesis in skeletal tissue, but is ineffective in adipose tissue: control of mesenchymal cell differentiation via integrin binding sites in extracellular matrices.The alpha2beta1 integrin inhibitor rhodocetin binds to the A-domain of the integrin alpha2 subunit proximal to the collagen-binding site.Building collagen IV smart scaffolds on the outside of cells.Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms.The triple helix of collagens - an ancient protein structure that enabled animal multicellularity and tissue evolution.
P2860
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P2860
The alpha 1 beta 1 integrin recognition site of the basement membrane collagen molecule [alpha 1(IV)]2 alpha 2(IV).
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
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1993年学术文章
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1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
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1993年學術文章
@zh-hant
name
The alpha 1 beta 1 integrin re ...... le [alpha 1(IV)]2 alpha 2(IV).
@en
type
label
The alpha 1 beta 1 integrin re ...... le [alpha 1(IV)]2 alpha 2(IV).
@en
prefLabel
The alpha 1 beta 1 integrin re ...... le [alpha 1(IV)]2 alpha 2(IV).
@en
P2093
P2860
P1433
P1476
The alpha 1 beta 1 integrin re ...... le [alpha 1(IV)]2 alpha 2(IV).
@en
P2093
P2860
P304
P407
P577
1993-12-01T00:00:00Z