Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
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Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genesThe histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolismLinks between metabolism and cancerThe emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancerTranslational development of difluoromethylornithine (DFMO) for the treatment of neuroblastomaMYC, Metabolism, and CancerOncogenes strike a balance between cellular growth and homeostasisMYC and metabolism on the path to cancerInterplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogrammingDiverse diseases from a ubiquitous process: the ribosomopathy paradoxOmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumorsRegulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New TricksRegulation of translation initiation in eukaryotes: mechanisms and biological targetsRegulation of rDNA transcription by proto-oncogene PELP1A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformationIdentification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma bruceiInhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53Carcinogenic effects of oil dispersants: a KEGG pathway-based RNA-seq study of human airway epithelial cellsMYC on the path to cancerGenetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancerPlk4 is required for cytokinesis and maintenance of chromosomal stability.Dysregulation of ribosome biogenesis and translational capacity is associated with tumor progression of human breast cancer cells.c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland.Haematopoietic stem cells require a highly regulated protein synthesis rate.Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytesTailor made protein synthesis for HSCs.New frontiers in translational control of the cancer genomeThe pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenanceGenetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4EMyc proteins as therapeutic targets.Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis.Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation.The cancerous translation apparatusThe tumor suppressive role of eIF3f and its function in translation inhibition and rRNA degradation.4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasisWhen ribosomes go bad: diseases of ribosome biogenesis.Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma.Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemiaRibosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications
P2860
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P2860
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
@en
type
label
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
@en
prefLabel
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
@en
P2093
P2860
P356
P1433
P1476
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
@en
P2093
Davide Ruggero
Maria Barna
Maria Costa
Nadya Kondrashov
Ornella Zollo
Pulivarthi H Rao
P2860
P2888
P304
P356
10.1038/NATURE07449
P407
P577
2008-11-16T00:00:00Z
P5875
P6179
1053320320