Phosphorylation of Par-4 by protein kinase A is critical for apoptosis. - Wikidata - awgldk - TriplyDB

Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.

Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.

http://www.wikidata.org/entity/Q40891090

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The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis Mechanisms of apoptosis by the tumor suppressor Par-4 Par-4: a new activator of myosin phosphatase Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells Prostate apoptosis response-4 is involved in the apoptosis response to docetaxel in MCF-7 breast cancer cells The Rubella virus capsid is an anti-apoptotic protein that attenuates the pore-forming ability of Bax.The Ras effector RASSF2 controls the PAR-4 tumor suppressor.Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model.Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection Reovirus receptors, cell entry, and proapoptotic signaling.Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity.Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.Apoptosis and tumor resistance conferred by Par-4 Post-translational regulation of the cleaved fragment of Par-4 in ovarian and endometrial cancer cells.TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity.Rubella virus capsid protein: a small protein with big functions.PAR-4 as a possible new target for pancreatic cancer therapy.Cancer-selective apoptotic effects of extracellular and intracellular Par-4.Par-4 as a potential target for cancer therapy.PAR-4: a possible new target for age-related disease.Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus.A journey beyond apoptosis: new enigma of controlling metastasis by pro-apoptotic Par-4.Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer.Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4 EGFR inhibitor enhances cisplatin sensitivity of human glioma cells.The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU.TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells.Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation.Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells.Structural basis for the regulatory interactions of proapoptotic Par-4.Par-4 is an essential downstream target of DAP-like kinase (Dlk) in Dlk/Par-4-mediated apoptosis.Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemia.Inhibition of CRM1 activity sensitizes endometrial and ovarian cell lines to TRAIL-induced cell death.

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Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.

http://www.wikidata.org/entity/Q40891090

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Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.

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Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.

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Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.

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MCB.25.3.1146-1161.2005

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Molecular and Cellular Biology

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Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.

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Anindya Goswami

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Krishna Murthi Vasudevan

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Sushma Gurumurthy

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Vivek M Rangnekar

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P2860

Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression

c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells

Human tumors associated with Carney complex and germline PRKAR1A mutations: a protein kinase A disease!

Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit.

Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase

The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression

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10.1128/MCB.25.3.1146-1161.2005

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8074856

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15657440

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apoptotic process

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544017

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