Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.
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The tumor suppressor Par-4 activates an extrinsic pathway for apoptosisMechanisms of apoptosis by the tumor suppressor Par-4Par-4: a new activator of myosin phosphataseRegulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cellsProstate apoptosis response-4 is involved in the apoptosis response to docetaxel in MCF-7 breast cancer cellsThe Rubella virus capsid is an anti-apoptotic protein that attenuates the pore-forming ability of Bax.The Ras effector RASSF2 controls the PAR-4 tumor suppressor.Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model.Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotectionReovirus receptors, cell entry, and proapoptotic signaling.Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in miceSyk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunitPar-4 binds to topoisomerase 1 and attenuates its DNA relaxation activityPar-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity.Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosisPar-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.Apoptosis and tumor resistance conferred by Par-4Post-translational regulation of the cleaved fragment of Par-4 in ovarian and endometrial cancer cells.TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cellsProstate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity.Rubella virus capsid protein: a small protein with big functions.PAR-4 as a possible new target for pancreatic cancer therapy.Cancer-selective apoptotic effects of extracellular and intracellular Par-4.Par-4 as a potential target for cancer therapy.PAR-4: a possible new target for age-related disease.Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus.A journey beyond apoptosis: new enigma of controlling metastasis by pro-apoptotic Par-4.Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer.Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survivalNovel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4EGFR inhibitor enhances cisplatin sensitivity of human glioma cells.The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU.TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells.Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation.Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells.Structural basis for the regulatory interactions of proapoptotic Par-4.Par-4 is an essential downstream target of DAP-like kinase (Dlk) in Dlk/Par-4-mediated apoptosis.Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemia.Inhibition of CRM1 activity sensitizes endometrial and ovarian cell lines to TRAIL-induced cell death.
P2860
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P2860
Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.
@en
type
label
Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.
@en
prefLabel
Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.
@en
P2093
P2860
P1476
Phosphorylation of Par-4 by protein kinase A is critical for apoptosis.
@en
P2093
Anindya Goswami
Krishna Murthi Vasudevan
Sushma Gurumurthy
Vivek M Rangnekar
P2860
P304
P356
10.1128/MCB.25.3.1146-1161.2005
P407
P577
2005-02-01T00:00:00Z