The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks.
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Bacterial Genotoxins: Merging the DNA Damage Response into Infection BiologyStructure of the Cyclomodulin Cif from Pathogenic Escherichia coliThe Cytolethal Distending Toxin Contributes to Microbial Virulence and Disease Pathogenesis by Acting As a Tri-Perditious ToxinThe Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.Study of the cytolethal distending toxin (CDT)-activated cell cycle checkpoint. Involvement of the CHK2 kinase.Cycle inhibiting factors (CIFs) are a growing family of functional cyclomodulins present in invertebrate and mammal bacterial pathogensCiclopirox inhibits cancer cell proliferation by suppression of Cdc25A.The cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective.Exposure of lymphocytes to high doses of Actinobacillus actinomycetemcomitans cytolethal distending toxin induces rapid onset of apoptosis-mediated DNA fragmentation.Interactions of Campylobacter jejuni cytolethal distending toxin subunits CdtA and CdtC with HeLa cellsDistinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending ToxinsThe struggle within: microbial influences on colorectal cancer.Crystallization of Escherichia coli CdtB, the biologically active subunit of cytolethal distending toxin.Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosisHigh prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer.Genomic Comparison of Campylobacter spp. and Their Potential for Zoonotic Transmission between Birds, Primates, and Livestock.Prevalence and pathogenic potential of campylobacter isolates from free-living, human-commensal american crows.Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression?The biology of the cytolethal distending toxinsBacterial toxin modulation of the eukaryotic cell cycle: are all cytolethal distending toxins created equally?Cellular internalization of cytolethal distending toxin from Haemophilus ducreyiCytolethal distending toxin demonstrates genotoxic activity in a yeast model.Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cellsBacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling.A CdtA-CdtC complex can block killing of HeLa cells by Haemophilus ducreyi cytolethal distending toxin.The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA.The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells.Biogenesis of the Actinobacillus actinomycetemcomitans cytolethal distending toxin holotoxin.An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus.Nuclear localization of the Escherichia coli cytolethal distending toxin CdtB subunit.DNase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest.The toxicity of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin correlates with its phosphatidylinositol-3,4,5-triphosphate phosphatase activity.From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin.Escherichia coli cyclomodulin Cif induces G2 arrest of the host cell cycle without activation of the DNA-damage checkpoint-signalling pathway.Cytolethal Distending Toxin: A Unique Variation on the AB Toxin Paradigm
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P2860
The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks.
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1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
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1999年學術文章
@zh-hant
name
The bacterial cytolethal diste ...... nduction of DNA strand breaks.
@en
type
label
The bacterial cytolethal diste ...... nduction of DNA strand breaks.
@en
prefLabel
The bacterial cytolethal diste ...... nduction of DNA strand breaks.
@en
P2093
P2860
P356
P1433
P1476
The bacterial cytolethal diste ...... induction of DNA strand breaks
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203007
P407
P577
1999-11-01T00:00:00Z
P5875
P6179
1042013956