Mutations uncouple human fibroblast growth factor (FGF)-7 biological activity and receptor binding and support broad specificity in the secondary receptor binding site of FGFs.
about
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily membersAlternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificityFibroblast growth factors share binding sites in heparan sulphate.The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor.Differential effects of heparin saccharides on the formation of specific fibroblast growth factor (FGF) and FGF receptor complexes.Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation.Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2.Structure-based mutational analyses in FGF7 identify new residues involved in specific interaction with FGFR2IIIb.Identification of residues important both for primary receptor binding and specificity in fibroblast growth factor-7.Similarities and differences between the effects of heparin and glypican-1 on the bioactivity of acidic fibroblast growth factor and the keratinocyte growth factor.
P2860
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P2860
Mutations uncouple human fibroblast growth factor (FGF)-7 biological activity and receptor binding and support broad specificity in the secondary receptor binding site of FGFs.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Mutations uncouple human fibro ...... receptor binding site of FGFs.
@en
type
label
Mutations uncouple human fibro ...... receptor binding site of FGFs.
@en
prefLabel
Mutations uncouple human fibro ...... receptor binding site of FGFs.
@en
P2093
P2860
P356
P1476
Mutations uncouple human fibro ...... receptor binding site of FGFs
@en
P2093
P2860
P304
35016-35022
P356
10.1074/JBC.274.49.35016
P407
P577
1999-12-01T00:00:00Z