Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity.
about
SUMO-1 conjugation to human DNA topoisomerase II isozymesTargeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisonsTopoisomerase levels determine chemotherapy responsein vitroandin vivoAssignment of functional amino acids around the active site of human DNA topoisomerase IIalpha.Screening a panel of drugs with diverse mechanisms of action yields potential therapeutic agents against neuroblastoma.Sensitivity to TOP2 targeting chemotherapeutics is regulated by Oct1 and FILIP1LDNA topoisomerases as targets for anticancer drugs.Predictive value of topoisomerase II alpha immunostaining in urothelial bladder carcinomaIdentification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles.The significance of Epstein Barr virus (EBV) & DNA topoisomerase II alpha (DNA-Topo II alpha) immunoreactivity in normal oral mucosa, oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC).Pharmacogenetics of genes across the doxorubicin pathway.A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.The alpha4 residues of human DNA topoisomerase IIalpha function in enzymatic activity and anticancer drug sensitivity.Isolation and characterization of mAMSA-hypersensitive mutants. Cytotoxicity of Top2 covalent complexes containing DNA single strand breaksDetection of the Epstein-Barr virus and DNA-topoisomerase II- α in recurrent and nonrecurrent giant cell lesion of the jawbonesHow does doxorubicin work?Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin.Atp-bound topoisomerase ii as a target for antitumor drugs.Topoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity.Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.The transducer domain is important for clamp operation in human DNA topoisomerase IIalpha.
P2860
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P2860
Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity.
@en
type
label
Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity.
@en
prefLabel
Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity.
@en
P2093
P356
P1433
P1476
Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity
@en
P2093
P304
10793-10800
P356
10.1021/BI9909804
P407
P577
1999-08-01T00:00:00Z