about
Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST]Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate.Impact of updated HER2 testing guidelines in breast cancer--re-evaluation of HERA trial fluorescence in situ hybridization data.Single-cell analysis of mtDNA deletion levels in sporadic amyotrophic lateral sclerosis.Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors.Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy.qPCR in gastrointestinal stromal tumors: Evaluation of reference genes and expression analysis of KIT and the alternative receptor tyrosine kinases FLT3, CSF1-R, PDGFRB, MET and AXL.A subset of gastrointestinal stromal tumors previously regarded as wild-type tumors carries somatic activating mutations in KIT exon 8 (p.D419del)Chromogenic in situ hybridization is a reliable assay for detection of ALK rearrangements in adenocarcinomas of the lung.c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasiaActivated RET and ROS: two new driver mutations in lung adenocarcinoma.FGFR1 amplifications in squamous cell carcinomas of the lung: diagnostic and therapeutic implications.Comparison of pre-analytical FFPE sample preparation methods and their impact on massively parallel sequencing in routine diagnosticsChallenging dedifferentiated liposarcoma identified by MDM2-amplification, a report of two cases.Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy.Residual tumor cells are unique cellular targets in glioblastoma.Clear cell papillary renal cell carcinoma and renal angiomyoadenomatous tumor: two variants of a morphologic, immunohistochemical, and genetic distinct entity of renal cell carcinoma.Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung CancerROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability.Ovarian-type epithelial tumours of the testis: immunohistochemical and molecular analysis of two serous borderline tumours of the testis.Heterogeneity of KRAS Mutation Status in Rectal CancerPartial Response to First-Line Crizotinib in an Elderly Male Patient with ROS1 Translocation-Positive Lung Cancer.Mutation analysis of gastrointestinal stromal tumors: increasing significance for risk assessment and effective targeted therapy.HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat.EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy.Integrative genome analyses identify key somatic driver mutations of small-cell lung cancerInterlaboratory-concordance of PD-L1 immunohistochemistry for non-small cell lung cancer.Current Standard and Future Perspectives in the Treatment of Gastrointestinal Stromal Tumors.SRC inhibition represents a potential therapeutic strategy in liposarcoma.FGFR2 is overexpressed in myxoid liposarcoma and inhibition of FGFR signaling impairs tumor growth in vitro.Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient - case report and review of clinicopathological features.miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours.Diagnostic red flags: steroid-treated malignant CNS lymphoma mimicking autoimmune inflammatory demyelination.Sensitive and specific detection of EML4-ALK rearrangements in non-small cell lung cancer (NSCLC) specimens by multiplex amplicon RNA massive parallel sequencing.Multicenter immunohistochemical ALK-testing of non-small-cell lung cancer shows high concordance after harmonization of techniques and interpretation criteria.Clinicopathological and molecular features of a large cohort of gastrointestinal stromal tumors (GISTs) and review of the literature: BRAF mutations in KIT/PDGFRA wild-type GISTs are rare events.MET gene copy number alterations and expression of MET and hepatocyte growth factor are potential biomarkers in angiosarcomas and undifferentiated pleomorphic sarcomas.Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors.Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas.Heterogeneous mechanisms of primary and acquired resistance to third-generation EGFR inhibitors.
P50
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P50
description
onderzoeker
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name
Hans-Ulrich Schildhaus
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Hans-Ulrich Schildhaus
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Hans-Ulrich Schildhaus
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Hans-Ulrich Schildhaus
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type
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Hans-Ulrich Schildhaus
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Hans-Ulrich Schildhaus
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Hans-Ulrich Schildhaus
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Hans-Ulrich Schildhaus
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prefLabel
Hans-Ulrich Schildhaus
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Hans-Ulrich Schildhaus
@en
Hans-Ulrich Schildhaus
@es
Hans-Ulrich Schildhaus
@sl