Current modulation and membrane targeting of the calcium channel alpha1C subunit are independent functions of the beta subunit.
about
TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.Molecular determinants of inactivation within the I-II linker of alpha1E (CaV2.3) calcium channels.A specific tryptophan in the I-II linker is a key determinant of beta-subunit binding and modulation in Ca(V)2.3 calcium channelsCoding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia.The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel functionThe ß subunit of voltage-gated Ca2+ channelsA CaVbeta SH3/guanylate kinase domain interaction regulates multiple properties of voltage-gated Ca2+ channels.Transfer of beta subunit regulation from high to low voltage-gated Ca2+ channels.Properties of voltage-gated Ca(2+) channels in rabbit ventricular myocytes expressing Ca(2+) channel alpha(1E) cDNA.Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neurons.Cooperation of two-domain Ca(2+) channel fragments in triad targeting and restoration of excitation- contraction coupling in skeletal muscle.Functional expression of the L-type calcium channel in mice skeletal muscle during prenatal myogenesis.Single-molecule imaging of l-type Ca(2+) channels in live cells.Organization of Ca2+ release units in excitable smooth muscle of the guinea-pig urinary bladderShort-term regulation of excitation-contraction coupling by the beta1a subunit in adult mouse skeletal muscle.Regulation of maximal open probability is a separable function of Ca(v)beta subunit in L-type Ca2+ channel, dependent on NH2 terminus of alpha1C (Ca(v)1.2alpha).Vascular calcium channels and high blood pressure: pathophysiology and therapeutic implications.Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivationA novel Ca(V)1.2 N terminus expressed in smooth muscle cells of resistance size arteries modifies channel regulation by auxiliary subunits.New Determinant for the CaVbeta2 subunit modulation of the CaV1.2 calcium channelIncreased CaVbeta1A expression with aging contributes to skeletal muscle weaknessStructure and function of the β subunit of voltage-gated Ca²⁺ channels.Synaptic localization and presynaptic function of calcium channel beta 4-subunits in cultured hippocampal neurons.A mutation in the beta interaction domain of the Ca(2+) channel alpha(1C) subunit reduces the affinity of the (+)-[(3)H]isradipine binding site.Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder.Calcium channel beta subunit promotes voltage-dependent modulation of alpha 1 B by G beta gamma.Ca(2+) channel inactivation heterogeneity reveals physiological unbinding of auxiliary beta subunits.A single CaVbeta can reconstitute both trafficking and macroscopic conductance of voltage-dependent calcium channels.Competitive and synergistic interactions of G protein beta(2) and Ca(2+) channel beta(1b) subunits with Ca(v)2.1 channels, revealed by mammalian two-hybrid and fluorescence resonance energy transfer measurements.A sequence in the carboxy-terminus of the alpha(1C) subunit important for targeting, conductance and open probability of L-type Ca(2+) channels.Modulation of the smooth-muscle L-type Ca2+ channel alpha1 subunit (alpha1C-b) by the beta2a subunit: a peptide which inhibits binding of beta to the I-II linker of alpha1 induces functional uncoupling.Molecular determinants of the CaVbeta-induced plasma membrane targeting of the CaV1.2 channel.The C-terminal residues in the alpha-interacting domain (AID) helix anchor CaV beta subunit interaction and modulation of CaV2.3 channels.Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx mice.The beta1a subunit regulates the functional properties of adult frog and mouse L-type Ca2+ channels of skeletal muscle.
P2860
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P2860
Current modulation and membrane targeting of the calcium channel alpha1C subunit are independent functions of the beta subunit.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Current modulation and membran ...... functions of the beta subunit.
@en
type
label
Current modulation and membran ...... functions of the beta subunit.
@en
prefLabel
Current modulation and membran ...... functions of the beta subunit.
@en
P2860
P50
P1476
Current modulation and membran ...... functions of the beta subunit
@en
P2093
P2860
P304
P356
10.1111/J.1469-7793.1999.0353T.X
P407
P478
517 ( Pt 2)
P577
1999-06-01T00:00:00Z