AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth.
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Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's diseaseProthrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic SystemReinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF productionNaringin: a protector of the nigrostriatal dopaminergic projection.Recent progress in the study of the Rheb family GTPases.Effects of naringin, a flavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brainMammalian target of rapamycin complex 1 as an inducer of neurotrophic factors in dopaminergic neurons.Roles of Rheb(S16H) in substantia nigra pars compacta dopaminergic neurons in vivoTargeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectivesActivation of CNTF/CNTFRα signaling pathway by hRheb(S16H) transduction of dopaminergic neurons in vivo.Inhibition of microglial activation and induction of neurotrophic factors by flavonoids: a potential therapeutic strategy against Parkinson's disease.Combined Nurr1 and Foxa2 roles in the therapy of Parkinson's disease.Expressing Constitutively Active Rheb in Adult Neurons after a Complete Spinal Cord Injury Enhances Axonal Regeneration beyond a Chondroitinase-Treated Glial Scar.Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson's diseaseExpressing Constitutively Active Rheb in Adult Dorsal Root Ganglion Neurons Enhances the Integration of Sensory Axons that Regenerate Across a Chondroitinase-Treated Dorsal Root Entry Zone Following Dorsal Root Crush.Enhancing the utility of adeno-associated virus gene transfer through inducible tissue-specific expression.Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains.(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis.Rheb GTPase regulates β-secretase levels and amyloid β generationmTOR in Brain Physiology and Pathologies.Retrograde Axonal Degeneration in Parkinson Disease.Induction of GDNF and BDNF by hRheb(S16H) transduction of SNpc neurons: neuroprotective mechanisms of hRheb(S16H) in a model of Parkinson's disease.Gene therapy approaches in the non-human primate model of Parkinson's disease.Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease.Pseudotyped Lentiviral Vectors for Retrograde Gene Delivery into Target Brain Regions.Expression mediated by three partial sequences of the human tyrosine hydroxylase promoter in vivo.Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative DisordersNaringin as a beneficial natural product against degeneration of the nigrostriatal dopaminergic projection in the adult brain.An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease.Quantitative morphological comparison of axon-targeting strategies for gene therapies directed to the nigro-striatal projection.Induction of axon growth in the adult brain: A new approach to restoration in Parkinson's disease.Combining Constitutively Active Rheb Expression and Chondroitinase Promotes Functional Axonal Regeneration after Cervical Spinal Cord Injury.Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo.Upregulation of neuronal astrocyte elevated gene-1 protects nigral dopaminergic neurons in vivo.Epothilone B Benefits Nigral Dopaminergic Neurons by Attenuating Microglia Activation in the 6-Hydroxydopamine Lesion Mouse Model of Parkinson's Disease
P2860
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P2860
AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
AAV transduction of dopamine n ...... on and mediates axon regrowth.
@en
type
label
AAV transduction of dopamine n ...... on and mediates axon regrowth.
@en
prefLabel
AAV transduction of dopamine n ...... on and mediates axon regrowth.
@en
P2093
P2860
P356
P1433
P1476
AAV transduction of dopamine n ...... ion and mediates axon regrowth
@en
P2093
Nikolai Kholodilov
Olga Yarygina
Sang Ryong Kim
Tatyana Kareva
P2860
P304
P356
10.1038/MT.2011.213
P577
2011-10-18T00:00:00Z