Sendai virus C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis.
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The C proteins of human parainfluenza virus type 1 block IFN signaling by binding and retaining Stat1 in perinuclear aggregates at the late endosomeThe nonstructural proteins of Nipah virus play a key role in pathogenicity in experimentally infected animals.Conserved charged amino acids within Sendai virus C protein play multiple roles in the evasion of innate immune responsesParamyxovirus replication and pathogenesis. Reverse genetics transforms understanding.Paramyxovirus reverse genetics is coming of age.Measles virus attenuation associated with transcriptional impediment and a few amino acid changes in the polymerase and accessory proteinsThe various Sendai virus C proteins are not functionally equivalent and exert both positive and negative effects on viral RNA accumulation during the course of infection.Versatility of the accessory C proteins of Sendai virus: contribution to virus assembly as an additional role.Sendai virus C proteins counteract the interferon-mediated induction of an antiviral stateSendai virus gene start signals are not equivalent in reinitiation capacity: moderation at the fusion protein gene.Comparison of predicted amino acid sequences of measles virus strains in the Edmonston vaccine lineage.Stringent requirement for the C protein of wild-type measles virus for growth both in vitro and in macaques.Inhibition of STAT 1 phosphorylation by human parainfluenza virus type 3 C protein.Y2, the smallest of the Sendai virus C proteins, is fully capable of both counteracting the antiviral action of interferons and inhibiting viral RNA synthesis.AIP1/Alix is a binding partner of Sendai virus C protein and facilitates virus budding.Paramyxovirus assembly and budding: building particles that transmit infections.The amino-terminal half of Sendai virus C protein is not responsible for either counteracting the antiviral action of interferons or down-regulating viral RNA synthesisThe amino-terminal extensions of the longer Sendai virus C proteins modulate pY701-Stat1 and bulk Stat1 levels independently of interferon signaling.Passage of a Sendai virus recombinant in embryonated chicken eggs leads to markedly rapid accumulation of U-to-C transitions in a limited region of the viral genomeParamyxovirus accessory proteins as interferon antagonists.The C proteins of human parainfluenza virus type 1 limit double-stranded RNA accumulation that would otherwise trigger activation of MDA5 and protein kinase RClustered basic amino acids of the small sendai virus C protein Y1 are critical to its RAN GTPase-mediated nuclear localization.Evolution and structural organization of the C proteins of paramyxovirinae.Attenuated and protease-profile modified sendai virus vectors as a new tool for virotherapy of solid tumors.Characterization of the amino acid residues of sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation.Expression of the Sendai (murine parainfluenza) virus C protein alleviates restriction of measles virus growth in mouse cells.Antagonism of innate immunity by paramyxovirus accessory proteins.The M2-2 protein of human respiratory syncytial virus is a regulatory factor involved in the balance between RNA replication and transcriptionSuppression of the Sendai virus M protein through a novel short interfering RNA approach inhibits viral particle production but does not affect viral RNA synthesisImportance of the anti-interferon capacity of Sendai virus C protein for pathogenicity in mice.IFN-β-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent mannerStructural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein.Human parainfluenza virus type 1 C proteins are nonessential proteins that inhibit the host interferon and apoptotic responses and are required for efficient replication in nonhuman primates.Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA.Studies on the paramyxovirus accessory genes by reverse genetics in the Sendai virus-mouse system.The C proteins of human parainfluenza virus type 1 (HPIV1) control the transcription of a broad array of cellular genes that would otherwise respond to HPIV1 infectionN-terminally truncated C protein, CNDelta25, of human parainfluenza virus type 3 is a potent inhibitor of viral replication.A novel human parainfluenza virus type 1 (HPIV1) with separated P and C genes is useful for generating C gene mutants for evaluation as live-attenuated virus vaccine candidates.Sendai virus C proteins regulate viral genome and antigenome synthesis to dictate the negative genome polarity.Respiratory syncytial virus that lacks open reading frame 2 of the M2 gene (M2-2) has altered growth characteristics and is attenuated in rodents
P2860
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P2860
Sendai virus C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Sendai virus C proteins are ca ...... replication and pathogenesis.
@en
type
label
Sendai virus C proteins are ca ...... replication and pathogenesis.
@en
prefLabel
Sendai virus C proteins are ca ...... replication and pathogenesis.
@en
P2093
P2860
P1433
P1476
Sendai virus C proteins are ca ...... replication and pathogenesis.
@en
P2093
Kiyotani K
Kurotani A
Mizumoto K
P2860
P304
P356
10.1046/J.1365-2443.1998.00170.X
P577
1998-02-01T00:00:00Z