T cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-zeta association.
about
T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformationAgeing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune systemConserved transmembrane tyrosine residues of the TCR beta chain are required for TCR expression and function in primary T cells and hybridomas.Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane.ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage.Activation outcomes induced in naïve CD8 T-cells by macrophages primed via "phagocytic" and nonphagocytic pathways.T cell receptor-mediated signal transduction controlled by the beta chain transmembrane domain: apoptosis-deficient cells display unbalanced mitogen-activated protein kinases activities upon T cell receptor engagement.Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.Fc receptor gamma chain residues at the interface of the cytoplasmic and transmembrane domains affect association with FcalphaRI, surface expression, and function.Structural Conservation and Effects of Alterations in T Cell Receptor Transmembrane Interfaces.Apoptosis-resistant T cells have a deficiency in NF-kappaB-mediated induction of Fas ligand transcription.
P2860
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P2860
T cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-zeta association.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
T cell receptor (TCR) engageme ...... ed ZAP70/CD3-zeta association.
@en
type
label
T cell receptor (TCR) engageme ...... ed ZAP70/CD3-zeta association.
@en
prefLabel
T cell receptor (TCR) engageme ...... ed ZAP70/CD3-zeta association.
@en
P2093
P2860
P356
P1476
T cell receptor (TCR) engageme ...... red ZAP70/CD3-zeta association
@en
P2093
A G Sahuquillo
E Teixeiro
P2860
P304
P356
10.1084/JEM.187.8.1179
P407
P50
P577
1998-04-01T00:00:00Z