Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.
about
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localizationGalphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblastsAurora A's Functions During Mitotic Exit: The Guess Who GameMolecular mechanisms controlling asymmetric and symmetric self-renewal of cancer stem cellsMolecular pathways regulating mitotic spindle orientation in animal cellsSpindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila.Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit.Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms?Asymmetric cell division of stem and progenitor cells during homeostasis and cancerAn essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamicsRegulation of glia number in Drosophila by Rap/Fzr, an activator of the anaphase-promoting complex, and Loco, an RGS proteinIntramolecular interactions between the SRC homology 3 and guanylate kinase domains of discs large regulate its function in asymmetric cell divisionPhosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity.Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells.Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts.Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemiaThe transcription factor Nerfin-1 prevents reversion of neurons into neural stem cellsMei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineageFunctional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumorsLineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain.Genetic mechanisms regulating stem cell self-renewal and differentiation in the central nervous system of Drosophila.Drosophila as a model for context-dependent tumorigenesis.Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.Phosphorylation and dephosphorylation events allow for rapid segregation of fate determinants during Drosophila neuroblast asymmetric divisions.Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth.Drosophila neuroblasts as a new model for the study of stem cell self-renewal and tumour formation.Regulation of asymmetric stem cell division: spindle orientation and the centrosome.The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidyThe bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch.Drosophila clueless is highly expressed in larval neuroblasts, affects mitochondrial localization and suppresses mitochondrial oxidative damage.Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon.Multiple Notch signaling events control Drosophila CNS midline neurogenesis, gliogenesis and neuronal identity.A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cellsIn vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells.Novel functions of endocytic player clathrin in mitosis.Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells.Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous systemklumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division.The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells.Warts phosphorylates mud to promote pins-mediated mitotic spindle orientation in Drosophila, independent of Yorkie.
P2860
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P2860
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Drosophila Aurora-A kinase inh ...... arity and spindle orientation.
@en
type
label
Drosophila Aurora-A kinase inh ...... arity and spindle orientation.
@en
prefLabel
Drosophila Aurora-A kinase inh ...... arity and spindle orientation.
@en
P2093
P2860
P356
P1433
P1476
Drosophila Aurora-A kinase inh ...... larity and spindle orientation
@en
P2093
Arash Bashirullah
Cheng-Yu Lee
Chris Q Doe
Khoa D Tran
Laurina Manning
Marcus J Lanskey
Ryan O Andersen
P2860
P304
P356
10.1101/GAD.1489406
P577
2006-12-01T00:00:00Z