Amyloid beta-protein and the genetics of Alzheimer's disease. - Wikidata - awgldk - TriplyDB

Amyloid beta-protein and the genetics of Alzheimer's disease.

Amyloid beta-protein and the genetics of Alzheimer's disease.

http://www.wikidata.org/entity/Q41074945

about

Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity Vaccination Strategies for Alzheimer???s Disease An atomic model for the pleated beta-sheet structure of abeta amyloid protofilaments Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein Lysophosphatidylcholine modulates fibril formation of amyloid beta peptide The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia Creation of non-human primate neurogenetic disease models by gene targeting and nuclear transfer Advances in development of fluorescent probes for detecting amyloid-β aggregates Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes Spines, plasticity, and cognition in Alzheimer's model mice Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid Progesterone receptors: form and function in brain Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening Presenilin 1 is required for maturation and cell surface accumulation of nicastrin Long-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in mice Amyloid-like fibril formation in an all beta-barrel protein involves the formation of partially structured intermediate(s).A new functional screening system for identification of regulators for the generation of amyloid beta-protein.Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex.Proinflammatory and vasoactive effects of Abeta in the cerebrovasculature.The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons.Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease.Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease.Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.A nucleated assembly mechanism of Alzheimer paired helical filaments.Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.The role of cell cycle-mediated events in Alzheimer's disease.Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Aβ42 DNA vaccine for Alzheimer disease.Cerebrovascular smooth muscle cell surface fibrillar A beta. Alteration of the proteolytic environment in the cerebral vessel wall.Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway.DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model.Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta.

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Amyloid beta-protein and the genetics of Alzheimer's disease.

http://www.wikidata.org/entity/Q41074945

description

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1996年學術文章

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1996年學術文章

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Amyloid beta-protein and the genetics of Alzheimer's disease.

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Amyloid beta-protein and the genetics of Alzheimer's disease.

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Journal of Biological Chemistry

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Amyloid beta-protein and the genetics of Alzheimer's disease.

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Selkoe DJ

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Apolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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