about
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptorCysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association StudiesA functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolatePharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitroLeukotrienes as mediators of asthma.Molecular and functional aspects of human cysteinyl leukotriene receptors.Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation.Transcellular biosynthesis of eicosanoid lipid mediators.In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends.The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors.Leukotriene modifiers in the treatment of cardiovascular diseases.Eicosanoids and their drugs in cardiovascular diseases: focus on atherosclerosis and stroke.Pharmacogenetics of the G protein-coupled receptors.Light on the structure of thromboxane A₂receptor heterodimers.The DRY motif and the four corners of the cubic ternary complex model.Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors.A role for inflammatory mediators in heterologous desensitization of CysLT1 receptor in human monocytes.Pharmacological characterization of 2NTX-99 [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a potential antiatherothrombotic agent with antithromboxane and nitric oxide donor activity in platelet and vascCysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras.Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT₂ receptor.CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation.Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor.Dual COXIB/TP antagonists: a possible new twist in NSAID pharmacology and cardiovascular risk.Facilitation of acetylcholine signaling by the dithiocarbamate fungicide propineb.Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma.Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation.Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling.Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways.Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents.Working hypothesis on the classification of Cys-leukotriene receptors in airways.CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation.Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo.Cysteinyl-leukotriene receptors and cellular signals.Corrigendum: Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 InhibitorsThe DRY motif at work: the P2Y12receptor caseLeukotrienes and AtherosclerosisAntagonism of thromboxane receptors by diclofenac and lumiracoxib
P50
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P50
description
hulumtuese
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researcher
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wetenschapper
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հետազոտող
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name
Valérie Capra
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Valérie Capra
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Valérie Capra
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Valérie Capra
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Valérie Capra
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type
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Valérie Capra
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Valérie Capra
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Valérie Capra
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Valérie Capra
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Valérie Capra
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Valérie Capra
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Valérie Capra
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Valérie Capra
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Valérie Capra
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Valérie Capra
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P1053
B-6225-2008
P106
P1153
7003313806
P21
P31
P3829
P496
0000-0003-3956-0833