Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels. - Wikidata - awgldk - TriplyDB

Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels.

Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels.

http://www.wikidata.org/entity/Q41126236

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Molecular and functional properties of P2X receptors--recent progress and persisting challenges Acid-sensing ion channels in pain and disease.The functional and anatomical dissection of somatosensory subpopulations using mouse genetics Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition Muscle IL1β Drives Ischemic Myalgia via ASIC3-Mediated Sensory Neuron Sensitization In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization.Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain.Neuromodulation by extracellular ATP and P2X receptors in the CNS.Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia.Regulation of ATP-gated P2X channels: from redox signaling to interactions with other proteins Subtype-specific mechanisms for functional interaction between α6β4* nicotinic acetylcholine receptors and P2X receptors Simultaneous disruption of mouse ASIC1a, ASIC2 and ASIC3 genes enhances cutaneous mechanosensitivity.Algogenic substances and metabolic status in work-related Trapezius Myalgia: a multivariate explorative study.ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain Anatomical and physiological factors contributing to chronic muscle pain Sensitization of group III and IV muscle afferents in the mouse after ischemia and reperfusion injury.Autozygome sequencing expands the horizon of human knockout research and provides novel insights into human phenotypic variation.Autonomic responses to exercise: group III/IV muscle afferents and fatigue.A mechanism-based approach to prevention of and therapy for fibromyalgia.Dry needling - peripheral and central considerations.PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls An antinociceptive role for substance P in acid-induced chronic muscle pain.Neurobiology of panic and pH chemosensation in the brain.Effect of Intramuscular Protons, Lactate, and ATP on Muscle Hyperalgesia in Rats.ASIC3 Is Required for Development of Fatigue-Induced Hyperalgesia.ENaCs and ASICs as therapeutic targets.Increased Interstitial Concentrations of Glutamate and Pyruvate in Vastus Lateralis of Women with Fibromyalgia Syndrome Are Normalized after an Exercise Intervention - A Case-Control Study.Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions.Dual Modulation of Nociception and Cardiovascular Reflexes during Peripheral Ischemia through P2Y1 Receptor-Dependent Sensitization of Muscle Afferents.IB4(+) nociceptors mediate persistent muscle pain induced by GDNF.Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits.Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids P2X₃ and TRPV1 functionally interact and mediate sensitization of trigeminal sensory neurons.Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems.Comprehensive phenotyping of group III and IV muscle afferents in mouse.The fundamental unit of pain is the cell.Mechanism of augmented exercise hyperpnea in chronic heart failure and dead space loading.Acid evoked thermal hyperalgesia involves peripheral P2Y1 receptor mediated TRPV1 phosphorylation in a rodent model of thrombus induced ischemic pain.

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Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels.

http://www.wikidata.org/entity/Q41126236

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Sensing muscle ischemia: coinc ...... interplay of two ion channels

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Edwin W McCleskey

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Frank G Williams

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John P Adelman

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Josephine Marsh-Haffner

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Leonardo Fierro

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Ligia A Naves

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Michelle Knowles

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Robert P Elde

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Valeria Spelta

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Wolfhard Almers

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P2860

Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

Crystal structure of the Aequorea victoria green fluorescent protein

TRP-PLIK, a bifunctional protein with kinase and ion channel activities

Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels

How do you feel? Interoception: the sense of the physiological condition of the body

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

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