Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.
about
Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of LckCBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migrationTyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activationPhosphorylation site dynamics of early T-cell receptor signalingFyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cellsThe lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling.Transmembrane adapters: attractants for cytoplasmic effectors.Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.Critical role of Ser-520 phosphorylation for membrane recruitment and activation of the ZAP-70 tyrosine kinase in T cells.ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domainsA novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant miceCD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins.ZAP-70: an essential kinase in T-cell signalingA PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-kappaB activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways.The role of CD45 and CD45-associated molecules in T cell activation.Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.Retrovirus-mediated transduction of primary ZAP-70-deficient human T cells results in the selective growth advantage of gene-corrected cells: implications for gene therapy.T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.Recruitment of calcineurin to the TCR positively regulates T cell activation.A mathematical analysis of TCR serial triggering and down-regulation.Nocodazole inhibits signal transduction by the T cell antigen receptor.
P2860
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P2860
Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Mutation of tyrosines 492/493 ...... l receptor signaling pathways.
@en
type
label
Mutation of tyrosines 492/493 ...... l receptor signaling pathways.
@en
prefLabel
Mutation of tyrosines 492/493 ...... l receptor signaling pathways.
@en
P2093
P2860
P356
P1476
Mutation of tyrosines 492/493 ...... l receptor signaling pathways.
@en
P2093
P2860
P304
32644-32652
P356
10.1074/JBC.271.51.32644
P407
P577
1996-12-01T00:00:00Z