Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer - Wikidata - awgldk - TriplyDB

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

http://www.wikidata.org/entity/Q41145824

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Development of multicellular tumor spheroid (MCTS) culture from breast cancer cell and a high throughput screening method using the MTT assay 3D Cultures of prostate cancer cells cultured in a novel high-throughput culture platform are more resistant to chemotherapeutics compared to cells cultured in monolayer In vitro microtumors provide a physiologically predictive tool for breast cancer therapeutic screening A bioengineered heterotypic stroma-cancer microenvironment model to study pancreatic ductal adenocarcinoma.3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D.Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip.Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment.The use of optical trap and microbeam to investigate the mechanical and transport characteristics of tunneling nanotubes in tumor spheroids.3D tissue-engineered model of Ewing's sarcoma The Role of Oxygen in Avascular Tumor Growth.Focal adhesion-chromatin linkage controls tumor cell resistance to radio- and chemotherapy Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening Transcriptome profile of the early stages of breast cancer tumoral spheroids Predictive models of diffusive nanoparticle transport in 3-dimensional tumor cell spheroids.Shape matters: the diffusion rates of TMV rods and CPMV icosahedrons in a spheroid model of extracellular matrix are distinct Long non-coding RNA H19 enhances cell proliferation and anchorage-independent growth of cervical cancer cell lines.Diffusion and Uptake of Tobacco Mosaic Virus as Therapeutic Carrier in Tumor Tissue: Effect of Nanoparticle Aspect Ratio High-resolution deep imaging of live cellular spheroids with light-sheet-based fluorescence microscopy.Calpain-dependent clearance of the autophagy protein p62/SQSTM1 is a contributor to ΔPK oncolytic activity in melanoma.The oncolytic virus ΔPK has multimodal anti-tumor activity.Liver kinase B1 enhances chemoresistance to gemcitabine in breast cancer MDA-MB-231 cells.Polymorphisms of monocarboxylate transporter genes are associated with clinical outcomes in patients with colorectal cancer.Targeting miR-21 for the therapy of pancreatic cancer Targeted deactivation of cancer-associated fibroblasts by β-catenin ablation suppresses melanoma growth.Malignant central nervous system tumors among adolescents and young adults (15-39 years old) in 14 Southern-Eastern European registries and the US Surveillance, Epidemiology, and End Results program: Mortality and survival patterns.Fully Automated One-Step Production of Functional 3D Tumor Spheroids for High-Content Screening.Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids Identifying the necrotic zone boundary in tumour spheroids with pair-correlation functions Quantitative three-dimensional evaluation of immunofluorescence staining for large whole mount spheroids with light sheet microscopy.Advanced cell culture techniques for cancer drug discovery.A method for estimating the oxygen consumption rate in multicellular tumour spheroids.Multi-size spheroid formation using microfluidic funnels.Using size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice.High-Content Monitoring of Drug Effects in a 3D Spheroid Model.Sarcoma Spheroids and Organoids-Promising Tools in the Era of Personalized Medicine.The Electrorotation as a Tool to Monitor the Dielectric Properties of Spheroid During the Permeabilization.Comparative Study of Multicellular Tumor Spheroid Formation Methods and Implications for Drug Screening.Oxygen diffusion in ellipsoidal tumour spheroids

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Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

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Multicellular tumor spheroid m ...... mbination in pancreatic cancer

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Annie Valette

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Bernard Ducommun

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Céline Frongia

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Isabelle Dufau

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Pierre Cordelier

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P2860

Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

Spheroid-based drug screen: considerations and practical approach

Chk1 is essential for tumor cell viability following activation of the replication checkpoint.

Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

Multicellular resistance: a paradigm for clinical resistance?

The use of 3-D cultures for high-throughput screening: the multicellular spheroid model.

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