The Domain II S4-S5 Linker in Nav1.9: A Missense Mutation Enhances Activation, Impairs Fast Inactivation, and Produces Human Painful Neuropathy.
about
Nav1.7 and other voltage-gated sodium channels as drug targets for pain reliefInfantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese FamiliesStructure-based assessment of disease-related mutations in human voltage-gated sodium channels.Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance.Novel sodium channel antagonists in the treatment of neuropathic pain.The Biophysical Basis Underlying Gating Changes in the p.V1316A Mutant Nav1.7 Channel and the Molecular Pathogenesis of Inherited Erythromelalgia.Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant.P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors.The CRISPR/Cas9 system for gene editing and its potential application in pain researchPathological nociceptors in two patients with erythromelalgia-like symptoms and rare genetic Nav 1.9 variantsA painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels.A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms.Pain transduction: a pharmacologic perspectiveGain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development.Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability.SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients.Electrophysiological and Pharmacological Analyses of Nav1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System.SFN-SIQ, SFNSL and skin biopsy of 55 cases with small fibre involvement.Sodium channels in pain disorders: pathophysiology and prospects for treatment.Voltage-gated sodium channels: (NaV )igating the field to determine their contribution to visceral nociception.NaV1.9 Potentiates Oxidized Phospholipid-Induced TRP Responses Only under Inflammatory Conditions.Genetic studies of human neuropathic pain conditions: a review.The Na1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons
P2860
Q28273870-2B56D059-2CE0-4744-95B1-83C035559EC6Q28552394-6567A7F1-7DD4-4E5A-A861-C7AB7DA39C0BQ33729032-3931ECA4-5502-4C41-AF6E-C44C1FAD1F69Q33806240-33FF60B4-C092-4081-9320-131093B5497EQ35843983-053007A2-2FFF-4116-B498-93F27BE27E93Q36139482-C91A06A1-7119-45F9-9840-E93BBDE2E86EQ36392068-B465C8CD-2BA8-4133-AECC-7E58370AC5B4Q36610295-2F7462A2-162D-46DF-A2D2-6569E7117C99Q37148023-44079333-C31F-4965-AAFE-E5CB0E585B24Q37339769-F0F55288-541D-47A2-AE45-7BB9BF4BF053Q37403813-BACF4F29-B342-4763-8AA1-D7602E6CF286Q38597831-77F35458-C628-4636-8E2E-70D6B6F5F728Q38823502-CB339EE2-0809-461B-A16F-9D16446B00CFQ39157361-93911563-DCF2-4EA4-990D-E2563588BA4BQ41661778-9A1EF1AF-49B6-4D4D-97D8-4292EA065CF0Q42283374-8F682A49-A1A0-4D12-8BE2-6182E7D403DEQ47141418-4EDC4541-5215-4D23-AE2C-2104936032ADQ47595493-2AA51D66-1FD2-4470-947B-22BB37426701Q47959907-E3DE4995-E980-429E-A4EC-45C6BB2C0A9EQ48273674-AEA9A2E6-E70D-4A67-A0E6-35A91A092D61Q49577397-4264E01B-6DD3-4A37-B521-C8834A488D40Q55240474-8DFD2000-2850-430B-BDC7-627E9E6D2CF1Q58764681-7928C06E-6802-4854-9C7F-65D63F668916
P2860
The Domain II S4-S5 Linker in Nav1.9: A Missense Mutation Enhances Activation, Impairs Fast Inactivation, and Produces Human Painful Neuropathy.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The Domain II S4-S5 Linker in ...... uces Human Painful Neuropathy.
@en
type
label
The Domain II S4-S5 Linker in ...... uces Human Painful Neuropathy.
@en
prefLabel
The Domain II S4-S5 Linker in ...... uces Human Painful Neuropathy.
@en
P2093
P2860
P50
P1476
The Domain II S4-S5 Linker in ...... duces Human Painful Neuropathy
@en
P2093
Bianca T A de Greef
Camiel Verhamme
Catharina G Faber
Chongyang Han
Ingemar S J Merkies
Janneke G J Hoeijmakers
Monique M Gerrits
Stephen G Waxman
Sulayman D Dib-Hajj
P2860
P2888
P304
P356
10.1007/S12017-015-8347-9
P577
2015-03-20T00:00:00Z