Scaleable processes for the synthesis of (-)-β-D-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (-)-β-D-2-aminopurine dioxolane (APD).

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Scaleable processes for the synthesis of (-)-β-D-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (-)-β-D-2-aminopurine dioxolane (APD).

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2012 nî lūn-bûn

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2012年の論文

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2012年論文

@yue

2012年論文

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2012年論文

@zh-hk

2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Scaleable processes for the sy ...... 2-aminopurine dioxolane (APD).

@en

type

Item

label

Scaleable processes for the sy ...... 2-aminopurine dioxolane (APD).

@en

prefLabel

Scaleable processes for the sy ...... 2-aminopurine dioxolane (APD).

@en

P1476

Scaleable processes for the sy ...... 2-aminopurine dioxolane (APD).

@en

P2093

Drew R Bobeck

http://www.w3.org/2001/XMLSchema#string

Hongwang Zhang

http://www.w3.org/2001/XMLSchema#string

Longhu Zhou

http://www.w3.org/2001/XMLSchema#string

Shi Junxing

http://www.w3.org/2001/XMLSchema#string

Steven J Coats

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P2860

Enantioselective synthesis of bicyclo[3.1.0]hexane carbocyclic nucleosides via a lipase-catalyzed asymmetric acetylation. Characterization of an unusual acetal byproduct

Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals

Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity

Mechanism of action and in vitro activity of 1',3'-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants

In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine

Anti-HIV-1 activities of 1,3-dioxolane guanine and 2,6-diaminopurine dioxolane

Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals.

Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys.

Enantioselective enzymatic desymmetrizations in organic synthesis.

Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs.

P304

5738-5743

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P31

scholarly article

P356

10.1016/J.TET.2012.05.039

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Raymond F. Schinazi

P577

2012-05-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23162170

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P932

3496293

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