IL-21 induces in vivo immune activation of NK cells and CD8(+) T cells in patients with metastatic melanoma and renal cell carcinoma. - Wikidata - awgldk - TriplyDB

IL-21 induces in vivo immune activation of NK cells and CD8(+) T cells in patients with metastatic melanoma and renal cell carcinoma.

IL-21 induces in vivo immune activation of NK cells and CD8(+) T cells in patients with metastatic melanoma and renal cell carcinoma.

http://www.wikidata.org/entity/Q41206789

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Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells The role of interleukin-21 in HIV infection Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21 IL-21: roles in immunopathology and cancer therapy Therapeutic cancer vaccines and combination immunotherapies involving vaccination Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study.Cytokines as Adjuvants for Vaccine and Cellular Therapies for Cancer.Advanced malignant melanoma: immunologic and multimodal therapeutic strategies Common gamma chain (γc) cytokines differentially potentiate TNFR family signaling in antigen-activated CD8(+) T cells Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replic A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer.IL-21R expression on CD8+ T cells promotes CD8+ T cell activation in coxsackievirus B3 induced myocarditis Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques Update on targeted therapies for clear cell renal cell carcinoma Role of IL-21 and IL-21 receptor on B cells in HIV infection.Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy.Interleukin 21: a cytokine/cytokine receptor system that has come of age Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.STAT3 regulates proliferation and survival of CD8+ T cells: enhances effector responses to HSV-1 infection, and inhibits IL-10+ regulatory CD8+ T cells in autoimmune uveitis.Immunotherapy of distant metastatic disease.Functions of γC cytokines in immune homeostasis: current and potential clinical applications.Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphoma.Tumor immune therapy: lessons from infection and implications for cancer - can IL-7 help overcome immune inhibitory networks?Vaccine-induced antibody responses in patients with carcinoma.Immune-related biomarkers for diagnosis/prognosis and therapy monitoring of cutaneous melanoma.Immunotherapy for metastatic melanoma.Combination strategies to enhance antitumor ADCC.Interleukin-21 and T follicular helper cells in HIV infection: research focus and future perspectives.Cancer-Induced Alterations of NK-Mediated Target Recognition: Current and Investigational Pharmacological Strategies Aiming at Restoring NK-Mediated Anti-Tumor Activity The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.A review on interleukins: The key manipulators in rheumatoid arthritis.Antitumor efficacy of viable tumor vaccine modified by heterogenetic ESAT-6 antigen and cytokine IL-21 in melanomatous mouse.GLP-1 Induces Barrier Protective Expression in Brunner's Glands and Regulates Colonic Inflammation.Local IL-21 promotes the therapeutic activity of effector T cells by decreasing regulatory T cells within the tumor microenvironment.Multivariate evaluation of pharmacological responses in early clinical trials - a study of rIL-21 in the treatment of patients with metastatic melanoma.IL-21/anti-Tim1/CD40 ligand promotes B10 activity in vitro and alleviates bone loss in experimental periodontitis in vivo.The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy.IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma.Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells

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IL-21 induces in vivo immune activation of NK cells and CD8(+) T cells in patients with metastatic melanoma and renal cell carcinoma.

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Cancer Immunology, Immunotherapy

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Birte K Skrumsager

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Dorthe Lundsgaard

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Ian D Davis

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Jeremy A Freeman

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Klaus Stensgaard Frederiksen

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Kresten Skak

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Lasse T Hansen

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Thomas L Holm

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P2860

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

Direct association of adenosine deaminase with a T cell activation antigen, CD26

Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells

The roles of IFN gamma in protection against tumor development and cancer immunoediting

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