(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.
about
Microtubule-stabilizing agents as potential therapeutics for neurodegenerative diseaseTubulin and FtsZ structures: functional and therapeutic implicationsNordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel.Mechanisms of Taxol resistance related to microtubules.(+)-Discodermolide: Total Synthesis, Construction of Novel Analogues, and Biological EvaluationChemistry and chemical biology of taxane anticancer agents.A common pharmacophore for cytotoxic natural products that stabilize microtubulesAnticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Microtubule stabilising agents for cancer chemotherapy.Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.24-Methyl-Cholesta-5,24(28)-Diene-3β,19-diol-7β-Monoacetate Inhibits Human Small Cell Lung Cancer Growth In Vitro and In Vivo via Apoptosis Induction.Structural Basis of Microtubule Stabilization by Discodermolide.Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin.MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications.Myriaporone 3/4 structure--activity relationship studies define a pharmacophore targeting eukaryotic protein synthesis.Human liver microsomal metabolism of (+)-discodermolide.Discodermolide interferes with the binding of tau protein to microtubules.Macromolecular accessibility of fluorescent taxoids bound at a paclitaxel binding site in the microtubule surface.Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin.Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners.Cascade Syntheses Routes to the Centrocountins
P2860
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P2860
(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
(+)-Discodermolide binds to mi ...... and results in mitotic arrest.
@en
type
label
(+)-Discodermolide binds to mi ...... and results in mitotic arrest.
@en
prefLabel
(+)-Discodermolide binds to mi ...... and results in mitotic arrest.
@en
P2093
P1476
(+)-Discodermolide binds to mi ...... and results in mitotic arrest.
@en
P2093
P304
P356
10.1016/S1074-5521(96)90108-8
P577
1996-04-01T00:00:00Z