Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. - Wikidata - awgldk - TriplyDB

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.

http://www.wikidata.org/entity/Q41218811

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Understanding specific functions of PARP-2: new lessons for cancer therapy Undercover: gene control by metabolites and metabolic enzymes Serine ADP-Ribosylation Depends on HPF1 PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue.The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection.ADPriboDB: The database of ADP-ribosylated proteins.PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas.PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes.Proteome-Wide Identification of In Vivo ADP-Ribose Acceptor Sites by Liquid Chromatography-Tandem Mass Spectrometry.NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair.Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1.Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets.Mass spectrometry for serine ADP-ribosylation? Think o-glycosylation!Serine ADP-ribosylation reversal by the hydrolase ARH3 Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues.PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules and impairment of Golgi complex functions.PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity.PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs.Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease.A Cell-Line-Specific Atlas of PARP-Mediated Protein Asp/Glu-ADP-Ribosylation in Breast Cancer.Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome.PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection.A macrodomain-linked immunosorbent assay (MLISA) for mono-ADP-ribosyltransferases.The role of poly ADP-ribosylation in the first wave of DNA damage response.Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation.Transcriptome-wide identification of the RNA-binding landscape of the chromatin-associated protein PARP1 reveals functions in RNA biogenesis.PAF1 regulation of promoter-proximal pause release via enhancer activation.Proteomic Analysis of the Downstream Signaling Network of PARP1.Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events.Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast.Insights into the biogenesis, function, and regulation of ADP-ribosylation.PARP-1-dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability.Gene-specific mechanisms direct Glucocorticoid Receptor-driven repression of inflammatory response genes in macrophages.Identification of Protein Substrates of Specific PARP Enzymes Using Analog-Sensitive PARP Mutants and a "Clickable" NAD+ Analog.Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci.Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes.Using Clickable NAD+ Analogs to Label Substrate Proteins of PARPs.Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress.

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Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.

http://www.wikidata.org/entity/Q41218811

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Chemical genetic discovery of ...... 1 in transcription elongation.

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Chemical genetic discovery of ...... 1 in transcription elongation.

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Bryan A Gibson

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Frank Schwede

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Hening Lin

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Hong Jiang

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Kristine M Hussey

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W Lee Kraus

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Yajie Zhang

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Yonghao Yu

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P2860

Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.

Stimulation of RNA polymerase II elongation by hepatitis delta antigen

Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach.

Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases.

Family-wide analysis of poly(ADP-ribose) polymerase activity

The emerging power of chemical genetics.

RNA polymerase II transcription elongation control.

Therapeutic applications of PARP inhibitors: anticancer therapy and beyond

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