Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.
about
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibioticsTreatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer AgentsAllostery in the Hsp70 chaperone proteinsUptake rate of cationic mitochondrial inhibitor MKT-077 determines cellular oxygen consumption change in carcinoma cellsIntrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression.Anticancer/antiviral agent Akt inhibitor-IV massively accumulates in mitochondria and potently disrupts cellular bioenergetics.Peptide deformylase inhibitors as potent antimycobacterial agents.Mitochondria: a target for cancer therapy.Chaperone proteins and brain tumors: potential targets and possible therapeutics.The mitochondrial death pathway: a promising therapeutic target in diseasesCorrelation between increased copy number of mitochondrial DNA and clinicopathological stage in colorectal cancer.Mitochondria: pharmacological manipulation of cell deathSynthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.Pharmacological targeting of the Hsp70 chaperone.Small mitochondria-targeting molecules as anti-cancer agents.Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis.Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70).Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.The isatin-Schiff base copper(II) complex Cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis.High Cytotoxic Activity of Phosphonium Salts and Their Complementary Selectivity towards HeLa and K562 Cancer Cells: Identification of Tri-n-butyl-n-hexadecylphosphonium bromide as a Highly Potent Anti-HeLa Phosphonium Salt.Tumor-Selective Cytotoxicity of Nitidine Results from Its Rapid Accumulation into MitochondriaThe active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.Mitochondrial autophagosomes as a mechanism of drug resistance in breast carcinoma.
P2860
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P2860
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.
@en
type
label
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.
@en
prefLabel
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.
@en
P2093
P1433
P1476
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077
@en
P2093
B T Brunelli
E Weisberg
J S Modica-Napolitano
P304
P407
P577
1996-02-01T00:00:00Z