Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males.
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Comorbidity Burden in Trial-Aligned Patients with Established Gout in Germany, UK, US, and France: a Retrospective Analysis.Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney.Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy adult male subjectsHyperuricemia, the kidneys, and the spectrum of associated diseases: a narrative review.Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study).Recent advances in understanding and managing goutLesinurad: A Review in Hyperuricaemia of Gout.Lesinurad Combined With Allopurinol: A Randomized, Double-Blind, Placebo-Controlled Study in Gout Patients With an Inadequate Response to Standard-of-Care Allopurinol (a US-Based Study).Lesinurad: what the nephrologist should know.Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout.The development of an effective synthetic route of lesinurad (RDEA594).Determination of lesinurad in rat plasma by a UHPLC-MS/MS assay.Lesinurad for the treatment of hyperuricaemia in people with gout.Lesinurad, a Selective URAT-1 Inhibitor With a Novel Mechanism in Combination With a Xanthine Oxidase Inhibitor, for Hyperuricemia Associated With Gout.Individualized treatment strategies for hyperuricemia informed by a semi-mechanistic exposure-response model of uric acid dynamics.Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and Commonly Used Drugs for Gout Treatment.Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and CYP Enzyme Substrates Sildenafil, Amlodipine, Tolbutamide, and Repaglinide.Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro
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P2860
Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
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2015年學術文章
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2015年學術文章
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2015年學術文章
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name
Pharmacokinetics, pharmacodyna ...... bitor, in healthy adult males.
@en
type
label
Pharmacokinetics, pharmacodyna ...... bitor, in healthy adult males.
@en
prefLabel
Pharmacokinetics, pharmacodyna ...... bitor, in healthy adult males.
@en
P2093
P2860
P356
P1476
Pharmacokinetics, pharmacodyna ...... bitor, in healthy adult males.
@en
P2093
Barry Quart
Chris Storgard
Colin Rowlings
Kimberly Manhard
Li-Tain Yeh
Vijay Hingorani
Zancong Shen
P2860
P304
P356
10.2147/DDDT.S85193
P407
P577
2015-07-02T00:00:00Z