Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.
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9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in MicePolyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transportRegulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbetaIdentification of ligands and coligands for the ecdysone-regulated gene switchAdvances in breast cancer treatment and prevention: preclinical studies on aromatase inhibitors and new selective estrogen receptor modulators (SERMs)The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta geneTranscription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptorsAdvances in drug design with RXR modulatorsPhytol metabolites are circulating dietary factors that activate the nuclear receptor RXRInduction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular targetRetinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptorSystematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's diseaseActivation of Retinoid X Receptor increases dopamine cell survival in models for Parkinson's disease.Characterization of a molecular switch system that regulates gene expression in mammalian cells through a small molecule.Potential retinoid x receptor agonists for treating Alzheimer's disease from traditional chinese medicine.Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver.The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesisAutoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency.Combination of physical activity, nutrition, or other metabolic factors and vaccine responseCombination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.Peroxisome proliferator-activated receptors in the cardiovascular system.The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.Retinoids in chemoprevention and differentiation therapy.Identification of macrophage liver X receptors as inhibitors of atherosclerosis.Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.Identification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion.Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.Function of RARalpha during the maturation of neutrophils.Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells.Spatiotemporal retinoid-X receptor activation detected in live vertebrate embryosActive Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancerAnalysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles.Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensorsCoexpression of nuclear receptor partners increases their solubility and biological activities.Modeling, synthesis and biological evaluation of potential retinoid X receptor-selective agonists: novel halogenated analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene)Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Coactivator recruitment is enhanced by thyroid hormone receptor trimers.Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha.
P2860
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P2860
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Design and synthesis of potent ...... e apoptosis in leukemia cells.
@en
type
label
Design and synthesis of potent ...... e apoptosis in leukemia cells.
@en
prefLabel
Design and synthesis of potent ...... e apoptosis in leukemia cells.
@en
P2093
P356
P1476
Design and synthesis of potent ...... e apoptosis in leukemia cells.
@en
P2093
McClurg MR
P304
P356
10.1021/JM00016A018
P407
P577
1995-08-01T00:00:00Z