A genetically detoxified derivative of heat-labile Escherichia coli enterotoxin induces neutralizing antibodies against the A subunit.
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Levels of expression and immunogenicity of attenuated Salmonella enterica serovar typhimurium strains expressing Escherichia coli mutant heat-labile enterotoxinCholera toxin, LT-I, LT-IIa and LT-IIb: the critical role of ganglioside binding in immunomodulation by type I and type II heat-labile enterotoxins.The region comprising amino acids 100 to 255 of Neisseria meningitidis lipoprotein GNA 1870 elicits bactericidal antibodies.Effects of site-directed mutagenesis of Escherichia coli heat-labile enterotoxin on ADP-ribosyltransferase activity and interaction with ADP-ribosylation factors.In vivo expression and immunoadjuvancy of a mutant of heat-labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio choleraeGenetically detoxified mutants of heat-labile toxin from Escherichia coli are able to act as oral adjuvants.Immunogenicity of the B monomer of Escherichia coli heat-labile toxin expressed on the surface of Streptococcus gordonii.Genetically manipulated bacterial toxin as a new generation mucosal adjuvant.Functional diversity of heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli: differential enzymatic and immunological activities of LT1 (hLT) AND LT4 (pLT)Mucosal vaccination against serogroup B meningococci: induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin.Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant.Evaluation of the LTK63 adjuvant effect on cellular immune responses to measles virus nucleoprotein.Mutants of the Escherichia coli heat-labile enterotoxin with reduced ADP-ribosylation activity or no activity retain the immunogenic properties of the native holotoxin.Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin.Murine antibody responses to the verotoxin 1 B subunit: demonstration of major histocompatibility complex dependence and an immunodominant epitope involving phenylalanine 30A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking.Evaluating the A-Subunit of the Heat-Labile Toxin (LT) As an Immunogen and a Protective Antigen Against Enterotoxigenic Escherichia coli (ETEC).Mucosal adjuvants and delivery systems for protein-, DNA- and RNA-based vaccines.The role of adjuvants in the development of mucosal vaccines.Intranuclear delivery of an antiviral peptide mediated by the B subunit of Escherichia coli heat-labile enterotoxin.The adjuvant LT-K63 can restore delayed maturation of follicular dendritic cells and poor persistence of both protein- and polysaccharide-specific antibody-secreting cells in neonatal miceNasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies.The Quest for an HIV-1 Vaccine Adjuvant: Bacterial Toxins as New Potential Platforms.Evaluation of the adjuvant effect of Escherichia coli heat-labile enterotoxin mutant (LTK63) on the systemic immune responses to intranasally co-administered measles virus nucleoprotein. Part I: antibody responses.Parenteral Adjuvant Effects of an Enterotoxigenic Escherichia coli Natural Heat-Labile Toxin VariantDendritic cell-targeting DNA-based mucosal adjuvants for the development of mucosal vaccinesBioadhesive delivery systems for mucosal vaccine delivery.Recent advances in vaccine adjuvants for systemic and mucosal administration.New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunizationConstruction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit.Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin.Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop.Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection.Directed delivery of heat-labile enterotoxin by enterotoxigenic Escherichia coli.Genetically detoxified mutants of heat-labile enterotoxin from Escherichia coli are effective adjuvants for induction of cytotoxic T-cell responses against HIV-1 gag-p55.Eradication of chronic Helicobacter pylori infection by therapeutic vaccination.Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity.Identification of an iron-sulfur cluster that modulates the enzymatic activity in NarE, a Neisseria meningitidis ADP-ribosyltransferaseApproaches to the Prevention and Treatment of Helicobacter pylori infection.The role of ADP-ribosylation and G(M1)-binding activity in the mucosal immunogenicity and adjuvanticity of the Escherichia coli heat-labile enterotoxin and Vibrio cholerae cholera toxin.
P2860
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P2860
A genetically detoxified derivative of heat-labile Escherichia coli enterotoxin induces neutralizing antibodies against the A subunit.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
A genetically detoxified deriv ...... ibodies against the A subunit.
@en
type
label
A genetically detoxified deriv ...... ibodies against the A subunit.
@en
prefLabel
A genetically detoxified deriv ...... ibodies against the A subunit.
@en
P2093
P2860
P356
P1476
A genetically detoxified deriv ...... ibodies against the A subunit.
@en
P2093
Domenighini M
Fontana MR
Giannelli V
Giuliani MM
Magagnoli C
P2860
P304
P356
10.1084/JEM.180.6.2147
P407
P577
1994-12-01T00:00:00Z