Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense.
about
AID and APOBECs span the gap between innate and adaptive immunityHistone chaperone Spt6 is required for class switch recombination but not somatic hypermutationThe Gut Microbiota and Immune System Relationship in Human Graft-versus-Host DiseaseHost-microbe interactions shaping the gastrointestinal environmentRegulation of frontline antibody responses by innate immune signals.Unique Features of Fish Immune Repertoires: Particularities of Adaptive Immunity Within the Largest Group of VertebratesGenetics and pathogenesis of inflammatory bowel diseaseRole of the microbiota in immunity and inflammation.The interplay between the gut microbiota and the immune system.Immune and genetic gardening of the intestinal microbiome.Microbial-immune cross-talk and regulation of the immune system.Microbiota-mediated colonization resistance against intestinal pathogens.Putting J chain back on the map: how might its expression define plasma cell development?Dietary resveratrol prevents the development of food allergy in mice.Role of secretory IgA in the mucosal sensing of commensal bacteria.Metagenomic cross-talk: the regulatory interplay between immunogenomics and the microbiome.Complex regulation and function of activation-induced cytidine deaminase.Shuttling of information between the mucosal and luminal environment drives intestinal homeostasis.Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.The role of the adaptive immune system in regulation of gut microbiota.Control of commensal microbiota by the adaptive immune system.Regulation of mucosal IgA responses: lessons from primary immunodeficiencies.Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota.Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestineRegulation of intestinal IgA responses.B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage.MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis.Fostering of advanced mutualism with gut microbiota by Immunoglobulin A.Functional flexibility of intestinal IgA - broadening the fine line.Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and PathogensThe Microbiome, Timing, and Barrier Function in the Context of Allergic Disease.Follicular Helper T Cells in Autoimmunity.Circulating Human CD27-IgA+ Memory B Cells Recognize Bacteria with Polyreactive IgsThe gastrointestinal tract: properties and role in allogeneic hematopoietic stem cell transplantation.Host-microbiota interactions in inflammatory bowel disease.Homeostatic Immunity and the Microbiota.Ancient T-independence of mucosal IgX/A: gut microbiota unaffected by larval thymectomy in Xenopus laevisIntestinal commensal microbes as immune modulators.Role of the gut microbiota in the development and function of lymphoid cells.Functional requirements of AID's higher order structures and their interaction with RNA-binding proteins
P2860
Q21131084-6720DFA0-3918-4CF4-990F-1725D98A4686Q24300395-DE54C9AA-2510-4590-B67C-1BB9D4F34AA2Q26751265-C0625686-BDC4-403C-8995-6B5F8791F466Q26829479-90FCBFE1-164A-46D3-B9C7-D37FBBF6EB45Q27686821-48E70C64-41F3-488C-8465-C3EEAFB85D6FQ28592953-ECB21C8D-BB0B-4562-B819-BA75FA29B3C2Q29616350-D1E3184E-73C5-4AB6-B873-6AC4DE41ABACQ33752553-7B5ABA58-9521-43F5-B805-A28D957F5A29Q34129422-88123F15-3A51-4E50-9134-200AA3ABA269Q34143465-F121B231-A16C-41BD-82D4-B64E4400F215Q34288647-3DA42532-933B-4D65-A543-2993CEC2BD1CQ34324937-5C06A29D-FBD2-4609-9DC5-5774348361BEQ34347803-340EBEC1-C7FB-4BC1-A886-D6F9BFB87DB4Q34409851-ACCDC499-CDD0-4B3F-A1A0-AB389BA52DE2Q34455427-89E8BA84-0281-4760-AD15-48278D248087Q34502460-BE026DB7-E13D-4A89-B1B7-ADF2EADE81DAQ34958445-341530D6-9EA9-4015-A2E4-8B4B2D1DF28AQ35121243-49B9D74A-F0AC-4C1A-A557-2A0BF9670D60Q35144590-16183B4C-E2EB-4993-899B-8D3F3FAA77C6Q35190715-6EFE72F2-036F-44DC-B836-2759DF68A310Q35611420-01259DEB-E150-4049-A39C-773C7FFE2E6DQ35619309-03785FA0-FFBB-430D-94E2-C1FFE0994B0FQ35683764-5D59C02E-6930-42A1-A803-40E48222F0F8Q35760860-8E5B4701-F0C5-4C5D-8831-FFE1846CA372Q35778680-F95B565E-1754-473D-8974-68229688ACC7Q35784554-0A6F6638-DFEA-46F4-BB99-7BA58E7E74EFQ35803149-8A5B3CFB-14E9-48F2-A5F3-4F66F92420E5Q35920077-17D02663-D23D-4C06-AE14-7D5C9EB65F24Q35929062-A0D39FCB-8D5D-45D2-B996-9007D8755E49Q35946361-9B7BC1E6-E9B6-4149-9E98-029FCCE09A52Q35994584-9D4DA18D-55E6-4A98-975C-63914AE01984Q36057301-1687D037-4E92-4C67-9346-0D5075DF8294Q36129466-284B9B26-A193-4EF9-BC87-13D1E6895F85Q36264109-0E6287DD-A265-45C3-92D8-F050EECC67ACQ36295242-8A0DD393-B170-4220-8228-0556367146D5Q36351062-7677E39F-64F3-4F9D-B4FC-149F6D647359Q36445901-8250D4DE-B541-4B25-B99C-A8F88269907CQ36451342-EDDB97AB-AECB-44C6-8840-26118B33F8B8Q36588140-3CC2F274-91C2-4F6A-A586-6B10C6D3D0D9Q36710679-CF3A8633-1221-4AF8-B21F-61F3BA99BBB3
P2860
Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Mice carrying a knock-in mutat ...... d compromised mucosal defense.
@en
type
label
Mice carrying a knock-in mutat ...... d compromised mucosal defense.
@en
prefLabel
Mice carrying a knock-in mutat ...... d compromised mucosal defense.
@en
P2093
P2860
P356
P1433
P1476
Mice carrying a knock-in mutat ...... d compromised mucosal defense.
@en
P2093
Mikako Maruya
Reiko Shinkura
Sidonia Fagarasan
Yasuko Doi
P2860
P2888
P304
P356
10.1038/NI.1991
P407
P50
P577
2011-01-23T00:00:00Z
P5875
P6179
1011886307