The developmental brain gene NPAS3 contains the largest number of accelerated regulatory sequences in the human genome.
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Can a few non-coding mutations make a human brain?The case for DUF1220 domain dosage as a primary contributor to anthropoid brain expansionMany human accelerated regions are developmental enhancersGenomic divergence and brain evolution: How regulatory DNA influences development of the cerebral cortexGenetic Markers of Human Evolution Are Enriched in Schizophrenia.Differential Gene Expression in the Human Brain Is Associated with Conserved, but Not Accelerated, Noncoding Sequences.An evolving view of epigenetic complexity in the brain.Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).NPAS3 variants in schizophrenia: a neuroimaging study.Neurodevelopmental LincRNA Microsyteny Conservation and Mammalian Brain Size Evolution.Integrative Tissue-Specific Functional Annotations in the Human Genome Provide Novel Insights on Many Complex Traits and Improve Signal Prioritization in Genome Wide Association Studies.Functional test of PCDHB11, the most human-specific neuronal surface proteinComprehensive identification and analysis of human accelerated regulatory DNAEvolution of Brain Active Gene Promoters in Human Lineage Towards the Increased Plasticity of Gene Regulation.Evolution of the Human Nervous System Function, Structure, and Development.Human evolution: the non-coding revolution.A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice.Evolution of transcriptional enhancers and animal diversity.Human accelerated regions and other human-specific sequence variations in the context of evolution and their relevance for brain development.Enhancing our brains: Genomic mechanisms underlying cortical evolution.Cumulative role of rare and common putative functional genetic variants at NPAS3 in schizophrenia susceptibility.Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity.PREDICTD PaRallel Epigenomics Data Imputation with Cloud-based Tensor Decomposition.
P2860
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P2860
The developmental brain gene NPAS3 contains the largest number of accelerated regulatory sequences in the human genome.
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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2013年论文
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2013年论文
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name
The developmental brain gene N ...... sequences in the human genome.
@en
type
label
The developmental brain gene N ...... sequences in the human genome.
@en
prefLabel
The developmental brain gene N ...... sequences in the human genome.
@en
P2093
P2860
P356
P1476
The developmental brain gene N ...... sequences in the human genome.
@en
P2093
Francisco Pisciottano
Gretel B Kamm
Lucía F Franchini
Rafi Kliger
P2860
P304
P356
10.1093/MOLBEV/MST023
P577
2013-02-13T00:00:00Z