Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
about
Dicyclic and tricyclic diaminopyrimidine derivatives as potent inhibitors of Cryptosporidium parvum dihydrofolate reductase: structure-activity and structure-selectivity correlations2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r(2)-guided region selection (q(2)-GRS) routine and its initial application.Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines.Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1)Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents.Dihydrofolate reductase inhibitors: developments in antiparasitic chemotherapy.Thymidylate synthase inhibition: a structure-based rationale for drug design.Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates.
P2860
Q28364098-919557A6-C8C3-4DB4-B633-423F106CB3B6Q33639893-DD182FA4-EE2D-4A58-A9CC-37512E9D8CA9Q33755029-05D5C14C-D384-4B7F-A2F0-1906944F1E66Q33899132-0595C4B9-FED3-47F9-920E-49269C75CDE7Q36899323-B30448A6-1D68-44C6-9FE7-D11293849B67Q37363530-C0E8D77E-7D5D-4DCC-8291-1E6AD63D3EF1Q37765574-7067EA67-1AB8-4C3C-B570-3E9C3F0054D8Q40872442-77F2406D-1B0E-4372-B355-7F84902FD17BQ42847105-BEC701B9-598A-4845-B8E3-5AE09D20248E
P2860
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Classical and nonclassical fur ...... sis and biological activities.
@en
type
label
Classical and nonclassical fur ...... sis and biological activities.
@en
prefLabel
Classical and nonclassical fur ...... sis and biological activities.
@en
P2093
P356
P1476
Classical and nonclassical fur ...... sis and biological activities.
@en
P2093
P304
P356
10.1021/JM00034A015
P407
P577
1994-04-01T00:00:00Z