Methylthioadenosine, a potent inhibitor of spermine synthase from bovine brain.
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Studies of inhibition of rat spermidine synthase and spermine synthaseGenomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancersStructure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysisCrystal Structure of Human Spermine Synthase: IMPLICATIONS OF SUBSTRATE BINDING AND CATALYTIC MECHANISMStructure ofStaphylococcus aureus5′-methylthioadenosine/S-adenosylhomocysteine nucleosidaseMechanism of substrate specificity in 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidasesEnzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidaseCrystal Structures of the Helicobacter pylori MTAN Enzyme Reveal Specific Interactions between S -Adenosylhomocysteine and the 5′-Alkylthio Binding SubsiteStructural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway.Aminopropyltransferases: function, structure and geneticsEscherichia coli S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of actionEffect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosineEffects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblastsOccurrence of 5'-deoxy-5'-methylthioadenosine phosphorylase in the mammalian CNS: distribution and kinetic studies on the rat brain enzymeAssessment of methylthioadenosine/S-adenosylhomocysteine nucleosidases of Borrelia burgdorferi as targets for novel antimicrobials using a novel high-throughput methodS-adenosylmethionine in liver health, injury, and cancer.Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism.Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesisIdentification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis.Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimicsStructure and inhibition of a quorum sensing target from Streptococcus pneumoniaePolyamines: from molecular biology to clinical applications.Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.Quantitation of cellular metabolic fluxes of methionine.Antitrypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives.A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers.Methylthioadenosine toxicity and metabolism to methionine in mammalian cells.Pfs promotes autolysis-dependent release of eDNA and biofilm formation in Staphylococcus aureus.Catabolism and lability of S-adenosyl-L-methionine in rat liver extracts.Purification and partial characterization of human polyamine synthasesThree-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design.Biosynthesis and metabolism of 9-[5'-deoxy-5'-(methylthio)-beta-D-xylofuranosyl]adenine, a novel natural analogue of methylthioadenosine.Specificity of mammalian spermidine synthase and spermine synthase.Affinity purification of 5-methylthioribose kinase and 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Klebsiella pneumoniae [corrected].Kinetic properties of spermine synthase from bovine brain.Inhibition of the synthesis of polyamines and macromolecules by 5'-methylthioadenosine and 5'-alkylthiotubercidins in BHK21 cells.Uptake and utilization of 5'-methylthioadenosine by cultured baby-hamster kidney cells.1,3-Diaminopropane rapidly inhibits protein synthesis and virus production in BKT-1 cells.
P2860
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P2860
Methylthioadenosine, a potent inhibitor of spermine synthase from bovine brain.
description
1979 nî lūn-bûn
@nan
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
1979年论文
@zh
1979年论文
@zh-cn
name
Methylthioadenosine, a potent inhibitor of spermine synthase from bovine brain.
@en
type
label
Methylthioadenosine, a potent inhibitor of spermine synthase from bovine brain.
@en
prefLabel
Methylthioadenosine, a potent inhibitor of spermine synthase from bovine brain.
@en
P2860
P1433
P1476
Methylthioadenosine, a potent inhibitor of spermine synthase from bovine brain.
@en
P2093
P2860
P304
P356
10.1016/0014-5793(79)80988-6
P407
P577
1979-03-01T00:00:00Z