GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes.
about
Long-lived plasma cells and memory B cells produce pathogenic anti-GAD65 autoantibodies in Stiff Person SyndromeType 1 Diabetes in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome (APECED): A "Rare" Manifestation in a "Rare" DiseaseAromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigenBlockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretionGAD65 antibodies, chronic psychosis, and type 2 diabetes mellitusMonoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats.Distinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis.Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.GAD antibody-associated limbic encephalitis in a young woman with APECED.Detection of autoantibodies against reactive oxygen species modified glutamic acid decarboxylase-65 in type 1 diabetes associated complicationsCharacterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes.Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia.Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions.Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar AtaxiasConsensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias.High definition profiling of autoantibodies to glutamic acid decarboxylases GAD65/GAD67 in stiff-person syndrome.Type 1 diabetes and polyglandular autoimmune syndrome: A reviewImmunobiology of stiff-person syndrome.Autoantibodies in insulin-dependent diabetes mellitus.Prediction and prevention of type I diabetes.Islet cell antibodies: variable immunostaining of pancreatic islet cells and carcinoid tissue.Immune-mediated cerebellar ataxias: from bench to bedside.Beta-cell rest: a strategy for the prevention of autoimmune diabetes.A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region.Peptidylarginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren syndrome.Autoimmune polyendocrine syndrome type 1 (APS I) in Norway.Novel neuronal and endocrine autoantibody targets in Autoimmune Polyendocrine Syndrome type 1.GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies.
P2860
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P2860
GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
GAD autoantibodies in IDDM, st ...... recognize different epitopes.
@en
type
label
GAD autoantibodies in IDDM, st ...... recognize different epitopes.
@en
prefLabel
GAD autoantibodies in IDDM, st ...... recognize different epitopes.
@en
P2093
P356
P1433
P1476
GAD autoantibodies in IDDM, st ...... recognize different epitopes.
@en
P2093
P304
P356
10.2337/DIAB.43.1.161
P407
P50
P577
1994-01-01T00:00:00Z